Shuke Jia
Chinese Academy of Sciences
13 Papers
Shuke Jia is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Medicine & Biology. The author has co-authored 1 publications.
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Papers
OTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation
Xing-Jun Liu,Hong-Bo Deng,Jinhua Tang,Zixuan Wang,Chunchun Zhu,Xiao-Jing Cai,Fangjing Rong,Xiaoyun Chen,Xueyi Sun,Shuke Jia,Gang Ouyang,Wenhua Li,Wuhan Xiao +12 more
TL;DR: In this article , the authors found that OTUB1 augments hypoxia signaling independent of PHDs/VHL and FIH, and showed that it positively regulates HIF-1α transcriptional activity.
Grass carp (Ctenopharyngodon idella) SIRT3 enhances MAVS-mediated antiviral innate immunity in response to GCRV infection
Chunchun Zhu,Wen Liu,Shuke Jia,Xueyi Sun,Zixuan Wang,Hong-Bo Deng,Yao Bai,Wuhan Xiao,Xing-Jun Liu +8 more
TL;DR: This study investigates the role of grass carp SIRT3 in antiviral innate immunity against GCRV infection, revealing its interaction with MAVS to enhance antiviral response and its essential enzymatic activity for antiviral function.
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Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance
Qian Liao,Chunchun Zhu,Xueyi Sun,Xiaoyun Chen,Hong-Bo Deng,Jinhua Tang,Shuke Jia,Wen Liu,Wuhan Xiao +8 more
TL;DR: It is found that sirt7-null zebrafish are more resistant to hypoxic conditions, along with an increase of hypoxia-responsive gene expression and erythrocyte numbers, compared with their wildtype siblings.
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Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3
Xing-Jun Liu,Jinhua Tang,Zixuan Wang,Chunchun Zhu,Hong-Bo Deng,Xueyi Sun,Guangqing Yu,Fangjing Rong,Xiaoyun Chen,Qian Liao,Shuke Jia,Wen Liu,Huangyuan Zha,Sijia Fan,Xiao-Jing Cai,Jian-Fang Gui +15 more
TL;DR: It is reported that during responses to viral infection, hypoxic conditions repress antiviral-responsive genes independently of HIF signaling, and EGLN1 is identified as a key mediator of the oxygen enhancement of antiviral innate immune responses.
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Oxygen potentiates antiviral ability of zebrafish in response to SVCV infection
Zixuan Wang,Chunchun Zhu,Xiaoyun Chen,Hong-Bo Deng,Xueyi Sun,Qian Liao,Shuke Jia,Wen Liu,Yao Bai,Wuhan Xiao,Xing-Jun Liu +10 more
TL;DR: This study investigates the effect of oxygen levels on antiviral responses in zebrafish infected with SVCV, revealing that low oxygen conditions increase susceptibility and promote virus replication, suppressing IFN activation.
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