Preparation methods, structural characteristics, and biological activity of polysaccharides from Salvia miltiorrhiza: A review.

Extraction, purification, structure characteristics, biological activities and pharmaceutical application of Bupleuri Radix Polysaccharide: A review.

To obtain the optimal process for the enzyme−assisted aqueous extraction of polysaccharides from Acanthopanax senticosus, and study the physicochemical properties of polysaccharides of different molecular weights, the extraction of Acanthopanax polysaccharides was optimized using the BBD response surface test. The polysaccharides with different molecular weights were obtained by ethanol−graded precipitation at 40%, 60%, and 80%, which were presented as ASPS40, ASPS60, and ASPS80. The polysaccharides were analyzed by HPGPC, ion chromatography, FT−IR, UV, SEM, TGA, XRD, Congo red, and I2−KI tests. The antioxidant assay was used to evaluate their antioxidant properties in vitro. The findings demonstrated that the recovery rate of Acanthopanax polysaccharide was 10.53 ± 0.682%, which is about 2.5 times greater compared to the conventional method of hot water extraction. Based on FT−IR, TGA, polysaccharides with different molecular weights did not differ in their structure or thermal stability. The XRD suggests that the internal structure of ASPSs is amorphous. Congo red and I2−KI showed that all three polysaccharides had triple helix structures with longer branched chains and more side chains. Furthermore, the antioxidant results showed the antioxidant activity of polysaccharides is not only related to the molecular weight size but also can be related to its composition and structure. These studies developed a green, and scalable method to produce polysaccharides from Acanthopanax senticosus and evaluated the properties of Acanthopanax polysaccharides of different molecular weights.

Optimization of Enzyme−Assisted Aqueous Extraction of Polysaccharide from Acanthopanax senticosus and Comparison of Physicochemical Properties and Bioactivities of Polysaccharides with Different Molecular Weights

Since ancient times, Tremella aurantialba has been proposed to have medicinal and food benefits. Modern phytochemistry and pharmacological studies have demonstrated that polysaccharides, the main components from T. aurantialba appear to be an all-round talent resisting a variety of chronic inflammatory diseases and protecting against different types of tumors, diabetes and cardiovascular diseases. These health and pharmacological benefits have gained much attention from scholars around the world. Further, more and more methods for polysaccharides extraction, purification, structure identification have been proposed. Significantly, the bioactivity of fungus polysaccharides is affected by many factors such as extraction and purification conditions and chemical structure. This paper provides an overview of recent advances in the isolation, structural features and biological effects of polysaccharides derived from T. aurantialba, covers recent advances in the field and outlines future research and applications of these polysaccharides.

/pdf/isolation-structures-bioactivities-application-and-future-uqome9p3.pdf

Isolation, structures, bioactivities, application and future prospective for polysaccharides from Tremella aurantialba: A review

Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, and mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as a viable alternative to conventional cancer treatments that encounter drug resistance. Nanotechnology has brought new advances in medicine and has shown great potential in drug delivery and cancer treatment. For precise and efficient therapeutic utilization of such a tumor therapeutic approach with high spatiotemporal selectivity and minimal invasiveness, the carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination therapy is essential. Utilizing natural products as the foundation for nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, and well biocompatibility. The natural-product-based, carrier-free, noncovalent NPs revealed excellent synergistic anticancer activity in comparison with free photosensitizers and free bioactive natural products, representing an alternative and favorable combination therapeutic avenue to improve therapeutic efficacy. Herein, a comprehensive summary of current strategies and representative application examples of carrier-free noncovalent NPs in the past decade based on natural products (such as paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, and curcumin) for tumor chemo-photodynamic combination therapy. We highlight the insightful design and synthesis of the smart carrier-free NPs that aim to enhance PDT efficacy. Meanwhile, we discuss the future challenges and potential opportunities associated with these NPs to provide new enlightenment, spur innovative ideas, and facilitate PDT-mediated clinical transformation. 

Natural-product-based, Carrier-free, Noncovalent Nanoparticles for Tumor Chemo-photodynamic Combination Therapy.

Optimisation of enzyme-assisted extraction of Erythronium sibiricum bulb polysaccharide and its effects on immunomodulation

Prodrug strategy is critical for innovative drug development. Structural modification is the most straightforward and effective method to develop prodrugs. Improving drug defects and optimizing the physical and chemical properties of a drug, such as lipophilicity and water solubility, changing the way of administration can be achieved through specific structural modification. Designing prodrugs by linking microenvironment-responsive groups to the prototype drugs is of great help in enhancing drug targeting. In the meantime, making connections between prodrugs and suitable drug delivery systems could realize drug loading increases, greater stability, bioavailability and drug release control. In this paper, lipidic, water-soluble, pH-responsive, redox-sensitive and enzyme-activatable prodrugs are reviewed on the basis of structural modification.

Structure modification: a successful tool for prodrug design.

An efficient compound enzyme extraction process was developed and optimized to extract the polysaccharide from Erythronium sibiricum bulb via response surface methodology. The polysaccharide E2P was obtained. Then, the preliminary characteristics of E2P were determined via colorimetry and chromatography. Additionally, the immunoregulatory activities of E2P and another polysaccharide (ESBP, extracted using the hot water method) were compared. The optimized extraction results were as follows: temperature (54.56 °C), time (2.52 h), pH (6.53), and enzyme concentration ratio (0.5% cellulase:1.5% amylase). The yield (64.18% ± 2.91%) obtained under the aforementioned conditions was considerably higher than the yield of ESBP (37.25% ± 0.17%). The total sugar, uronic acid, starch, and protein contents of E2P were 81.77% ± 2.84%, 3.31% ± 0.45%, 3.29% ± 0.01%, and 0.24% ± 0.02%, respectively. The HPLC result suggested that the predominant monosaccharides of E2P included glucose, galactose, and arabinose, with a molar ratio of 543.2:1:1.8. The in vitro tests in RAW264.7 cells indicated that ESBP exhibited better immunomodulatory activities than E2P. In particular, ESBP can promote the proliferation, phagocytosis, and cytokine secretion abilities of cytokines, such as nitric oxide, tumor necrosis factor-α, and interleukin (IL)-1β of RAW264.6 cells. By contrast, E2P can only promote phagocytosis ability and the secretion of IL-1β.

Optimization of the composite enzyme extraction of polysaccharide from Erythronium sibiricum bulb and its immunoregulatory activities.

Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system

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Optimisation of enzyme-assisted extraction of Erythronium sibiricum bulb polysaccharide and its effects on immunomodulation

Structure modification: a successful tool for prodrug design.

Optimization of the composite enzyme extraction of polysaccharide from Erythronium sibiricum bulb and its immunoregulatory activities.

Lipid-based formulations: A promising approach for poorly soluble drug delivery via the intestinal lymphatic system