Shujie Hou
Georgetown University Medical Center
24 Papers
183 Citations
Shujie Hou is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Tetrasaccharide & Glycoconjugate. The author has an hindex of 10, co-authored 23 publications. Previous affiliations of Shujie Hou include National Institutes of Health & Peking Union Medical College.
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Papers
Preparation of glycoconjugates by dialkyl squarate chemistry revisited.
TL;DR: D dimethyl squarate seemed to be the most convenient reagent for conversion of carbohydrate derivatives to species amenable for conjugation because it is a crystalline, easy to handle, and commercially available material with very good reactivity.
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Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.
Shujie Hou,Yong Weon Yi,Hyo Jin Kang,Li Zhang,Hee Jeong Kim,Yali Kong,Yong Liu,Kan Wang,Hye-Sik Kong,Scott Grindrod,Insoo Bae,Milton L. Brown +11 more
TL;DR: In vitro and in vivo studies showed that the inhibitory effects of 12 on phospho-STAT3 were through up-regulation of the protein-tyrosine phosphatase PTPN6, strongly support the continued preclinical evaluation of compound 12 as a potential chemotherapeutic agent for TNBC and cancers with constitutive STAT3 signaling.
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides
TL;DR: Two representative spirostanol saponins that have the typical structure for the sugar moiety, diosgenyl alpha-L-rhamnopyranosyl and dioscin, were easily synthesized by a general approach.
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Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
TL;DR: A novel carbazole SH-I-14 that decreased the level of the acetyl-STAT3 at the K685 residue resulted in re-expression of tumor suppressor genes such as VHL and PDLIM4 through de-methylation of their promoter regions.
Synthesis and antitumor activity of icogenin and its analogue.
TL;DR: It was observed that icogenin and its analogue show potent antitumor activity in vitro.
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