Shuang Lu
8 Papers
Shuang Lu is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 7 publications.
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Papers
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
Meiling Zheng,Zhi Hu,Xiaole Mei,Lianlian Ouyang,Yang Song,Wen-Hui Zhou,Yi Kong,Ruifang Wu,Shijia Rao,Hai Long,Wei Shi,Hui Jing,Shuang Lu,Haijing Wu,Su-Jie Jia,Qianjin Lu,Mingjing Zhao +16 more
TL;DR: In this paper , single-cell RNA sequencing data of cutaneous lesions from Discoid Lupus erythematosus (DLE) and SLE patients and skin tissues from healthy controls (HCs) were shown.
Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes
Xiao-Shan Min,Meiling Zheng,Yaqin Yu,Jiali Wu,Qiqi Kuang,Zhi Hu,Lianlian Ouyang,Shuang Lu,Mingjing Zhao +8 more
TL;DR: It is demonstrated that UVB irradiation‐induced activation of human endogenous retroviruses (HERVs) plays a major role in the immune response and the dsRNA‐sensing innate immunity pathway promotes type I IFN production, which may be a potential mechanism of skin inflammatory response and skin lesion of SLE/DLE.
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Integration of metabolomics and lipidomics reveals serum biomarkers for systemic lupus erythematosus with different organs involvement.
Wen-Qiang Zhang,Hongjun Zhao,Pei Du,Haobo Cui,Shuang Lu,Zhongyuan Xiang,Qianjin Lu,Su-Jie Jia,Mingjing Zhao +8 more
TL;DR: In this article , the authors performed metabolomic and lipidomic profiles analyses of 133 systemic lupus erythematosus (SLE) patients and 30 HCs, and found that a combination of four metabolites or lipids could distinguish SLE from HC with an AUC of 0.998.
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m6A methyltransferase METTL3 programs CD4+ T-cell activation and effector T-cell differentiation in systemic lupus erythematosus
Shuang Lu,Xingyu Wei,Huan Zhu,Zhi Hu,Meiling Zheng,Jiali Wu,Cheng Zhao,Shuang Yang,Delong Feng,Su-Jie Jia,Hongjun Zhao,Mingjing Zhao +11 more
TL;DR: In this article , the role of the m 6 A methyltransferase like 3 (METTL3) in CD4 + T-cell activation, differentiation, and SLE pathogenesis was investigated both in vitro and in vivo.
RNA N6-methyladenosine methylation and skin diseases.
TL;DR: Wang et al. as mentioned in this paper presented a review of m6A-related modifiers and their roles in RNA processing, and then focused on the existing research advances of M6A in immune homeostasis and skin diseases.
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