Shu Yan
Harvard University
7 Papers
4 Citations
Shu Yan is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Shu Yan include University of Maryland, Baltimore.
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Papers
Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
Zhonghan Yang,Zhonghan Yang,Viktoriya Grinchuk,Joseph F. Urban,Jennifer A. Bohl,Rex Sun,Luigi Notari,Shu Yan,Thirumalai R. Ramalingam,Achsah D. Keegan,Thomas A. Wynn,Terez Shea-Donohue,Aiping Zhao +12 more
TL;DR: It is demonstrated that macrophages as IL-25/IL-33-responsive cells play an important role in inducing type 2 immunity using both in vitro and in vivo approaches, and represent a unique population of the innate immune cells pivotal totype 2 immunity and a potential therapeutic target in controlling type 1 immunity-mediated inflammatory pathologies.
Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease
Gloria Serena,Shu Yan,Stephanie Camhi,Shilpi Patel,Rosiane Lima,Anna Sapone,Maureen M. Leonard,Rupa Mukherjee,Barbara J. Nath,Karen M. Lammers,Alessio Fasano +10 more
TL;DR: In this article, the authors showed that the combination of interferon (IFN)-γ and butyrate triggers the balance between FoxP3 isoforms in HC subjects, while the same does not occur in CD patients.
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Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members
Maureen M. Leonard,Stephanie Camhi,Victoria Kenyon,Rebecca A. Betensky,Craig Sturgeon,Shu Yan,Alessio Fasano +6 more
TL;DR: Modelling the frequency of CD autoimmunity (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D and their FDRs found that having both DR7-DQ2 and DR4-D Q8 was associated with an increased frequency of CDA.
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IL-25-Induced Immunotherapy Against Obesity and the Associated Metabolic Syndrome
Viktoriya Grinchuk,Zhonghan Yang,Allen Smith,Bolin Qin,Jennifer A. Stiltz,Rex Sun,Luigi Notari,Shu Yan,Joseph F. Urban,Terez Shea-Donohue,Aiping Zhao +10 more
TL;DR: UES contractile response to slow esophageal fluid distention is defective in patients with complaints of regurgitation and supraesophageAL complications, allowing escape of refluxate into the pharynx and UES response to esophagopharyngeal slow fluid infusion can serve as a test for recognizing this defect.
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Mechanisms Involved in the Development of the Chronic Gastrointestinal Syndrome in Nonhuman Primates after Total-Body Irradiation with Bone Marrow Shielding
Terez Shea-Donohue,Alessio Fasano,Aiping Zhao,Luigi Notari,Shu Yan,Rex Sun,Jennifer A. Bohl,Neemesh Desai,Greg L. Tudor,Motoko Morimoto,Catherine Booth,Alexander Bennett,Ann M. Farese,Thomas J. MacVittie +13 more
TL;DR: Data indicate that even a threshold dose of 10 Gy TBI-BM5 induces a persistent impairment of both mucosal barrier function and restitution in the GI tract and that ALP may serve as a biomarker for these events.