Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review.

A bioassay-guided phytochemical investigation of the leaves of Casearia balansae led to the isolation of six new cucurbitane-type triterpenoid derivatives (balanterpenes A–F, 1–6) and four new clerdoane-type diterpenoids (balanterpenes G–J, 7–10). The structures of 1–10 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Compound 1 features a ring-expanded triterpenoid skeleton with the C-19 methyl involved in the ring formation, compound 6 possesses a rare hexanortriterpenoid scaffold, and compounds 7–10 may be four new diterpenoid artifacts presumably formed during the extraction and purification processes. Compounds 3 and 7–10 showed promoting effects on neurite outgrowth of PC12 cells with EC50 values in the range 2.9–10.0 μM.

Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells.

Developing a simple, rapid, and accurate sensing platform to detect tyramine (Tyr), an indicator of food spoilage, is tremendously significant for food safety and human health. Here, two novel isostructural...

Lanthanide-MOFs based Host-guest Intelligent Dual-Stimulus Response Platform for Naked-eye and Ratiometric Fluorescent Monitoring of Food Freshness

A novel cycloartane triterpenoid alkaloid, kleinhospitine E (1), six new cycloartane triterpenoids (2–7), three known cycloartane triterpenoids (8–10), and taraxerone (11) were isolated from a methanol extract of Kleinhovia hospita Their structures were elucidated by 1D- and 2D-NMR spectroscopy as well as HRMS analysis The absolute configurations of all isolated compounds were determined from their ECD spectra by comparison with theoretical values Kleinhospitine E (1) is the first cycloartane alkaloid possessing an unusual γ-lactam with an oxopropylidene side chain Compounds 2, 3, and 6 were assigned as cycloartane triterpenoids with a 9α,10α-cyclopropyl ring, which is found rarely among naturally occurring compounds, while 4 and 5 were established as isomers of compound 3 containing a 21,23-diacetal side chain Biological evaluation revealed that compounds 4 and 9 exhibited more potent antiproliferative activities against a multidrug-resistant tumor cell line compared with its parent chemosensitive c

/pdf/kleinhospitine-e-and-cycloartane-triterpenoids-from-27w8zen45l.pdf

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita

Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18.

A phytochemical study on the rhizomes of Cimicifuga foetida resulted in the isolation of two new cycloartane triterpenoids (1 and 2), eight new cycloartane glycosides (3–10), and six known cycloartane glycoside analogues (11–16). The structures of 1–10 were determined by application of spectroscopic methods, with the absolute configuration of 1 determined by X-ray crystallography. Compounds 1–6, as three pairs of epimers at C-10 and C-24, belong to a seven-membered-ring variant of 9,10-seco-9,19-cycloartane triterpenoids, and glycosides 3–10 were found to be 3-O-β-d-xylopyranosides. The cytotoxicity of the isolates was evaluated against five selected human tumor cell lines, and the known compounds 15 and 16 showed cytotoxicity against the hepatocellular carcinoma SMMC-7721 cell line with IC50 values of 5.5 and 6.3 μM, respectively.

Cycloartane triterpenoids and their glycosides from the rhizomes of Cimicifuga foetida

Luminescent stability is a vital factor that dictates the application of lanthanide luminescent materials. Designing luminescent lanthanide cluster nodes that form an extended framework with predictable linking patterns may help enhance the structural stability of the lanthanide complexes and hence lead to improved luminescent stability. Herein, we report a series of one-dimensional (1D) rare-earth metal-organic framework compounds, {Ln4(μ4-OH)(TC4A)2(H2O)2(CH3O)(HCOO)2(HCOOH)}·xCH3OH (Ln = Sm (1), Eu (2), Tb (3), Dy (4); x = 1-5), based on double thiacalix[4]arene-capped Ln4(μ4-OH)(TC4A)2 nodes. The axially capped Ln4(μ4-OH)(TC4A)2 nodes are connected equatorially by formate bridges to form zigzag 1D-metal-organic framework (MOF) chains, which further assemble into a quasi-two-dimensional (2D) structure via hydrogen bonding. These unique features result in a stable structure and therefore superior luminescent stability. For example, the Tb-based 1D-MOF (3) exhibits intensive green photoluminescence with a quantum yield of 53% and an average decay time of 1.33 × 106 ns. It maintains its integrated emission intensity at 96.5, 94.5, and 89.4% of the original value after being exposed to moisture (soaking in water for 10 days), elevated temperature (150 °C), and UV (15 days of continuous radiation), respectively, demonstrating excellent luminescent stability. We adopt the Tb-based 1D-MOF (3) as the green phosphor and successfully fabricate a prototype white-light-emitting diode (LED) with stable emission under long-term operation. Our synthetic strategy allows control over the linking pattern of lanthanide nodes, providing a predictive route to obtain lanthanide MOFs with improved luminescent stability.

Ultrastable Photoluminescence Enabled by 1D Rare-Earth Metal-Organic Frameworks Based on Double Thiacalix[4]arene-Capped Nodes.

Indole alkaloid compound separated from rhizoma cimicifugae as well as preparation method and application thereof

Luminescence stability is a critical consideration for applying phosphors in practical devices. In this work, we report two categories of double p-tert-butylthiacalix[4]arene (H4TC4A) capped clusters that exhibit characteristic lanthanide luminescence. Specifically, {[Ln4(μ4-OH)(TC4A)2(DMF)6(CH3OH)3(HCOO)Cl2]}·xCH3OH (Ln = Eu (1), Tb (2); x = 0–1) with square-planar [Ln4(μ4-OH)] cluster cores and {[Ln9(μ5-OH)2(μ3-OH)8(OCH3) (TC4A)2 (H2O)24Cl9]}·xDMF (Ln = Gd (3), Tb (4), Dy (5); x = 2–6) with hourglass-like [Ln9(μ5-OH)2(μ3-OH)8] cluster cores are synthesized and characterized. By comparing 2 and 4, we find that several critical luminescence properties (such as quantum efficiency and luminescence stabilities) depend directly on the cluster core structure. With the square-planar [Ln4(μ4-OH)] cluster cores, 2 demonstrates high quantum yield (∼65%) and excellent luminescence stability against moisture, high temperature, and UV-radiation. A white light-emitting diode (LED) with ultrahigh color quality is successfully fabricated by mixing 2 with commercial phosphors. These results imply that high quality phosphors might be achieved by exploiting the double thiacalix[4]arene-capping strategy, with an emphasis on the cluster core structure.

/pdf/achieving-stable-photoluminescence-by-double-thiacalix-4-2d48izjj.pdf

Achieving stable photoluminescence by double thiacalix[4]arene-capping: the lanthanide-oxo cluster core matters

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Cycloartane triterpenoids and their glycosides from the rhizomes of Cimicifuga foetida

Ultrastable Photoluminescence Enabled by 1D Rare-Earth Metal-Organic Frameworks Based on Double Thiacalix[4]arene-Capped Nodes.

Indole alkaloid compound separated from rhizoma cimicifugae as well as preparation method and application thereof

Achieving stable photoluminescence by double thiacalix[4]arene-capping: the lanthanide-oxo cluster core matters