Shinya Yamamoto
Kanazawa University
6 Papers
70 Citations
Shinya Yamamoto is an academic researcher from Kanazawa University. The author has contributed to research in topics: Protein kinase A & Alkaline phosphatase. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Shinya Yamamoto include Tokyo Medical and Dental University.
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Papers
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Hiroyuki Sawanishi,Hirokazu Suzuki,Shinya Yamamoto,Yoshihiro Waki,Shohei Kasugai,Keiichi Ohya,Nagao Suzuki,Miyamoto Kenichi,Kenzo Takagi +8 more
TL;DR: Among them, 3,4-dipropyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-i]-purin-5-one (1c), which was the most selective and potent PDE IV inhibitor, did not cause emesis in Suncus murinus at a dosage range of 10-100 mg/kg (po), while an imidazole analogue of 1c (4c)
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Prostaglandin E2‐Mediated Anabolic Effect of a Novel Inhibitor of Phosphodiesterase 4, XT‐611, in the In Vitro Bone Marrow Culture
Ken-ichi Miyamoto,Hirokazu Suzuki,Shinya Yamamoto,Yukie Saitoh,Eiji Ochiai,Shuzo Moritani,Koichi Yokogawa,Yoshihiro Waki,Shohei Kasugai,Hiroyuki Sawanishi,Hideomi Yamagami +10 more
TL;DR: The mechanism of osteoblast formation by a novel PDE4 inhibitor, XT‐611, was studied in the in vitro bone marrow culture system and potentiated the osteoblastic differentiation through accumulation of cyclic AMP after autocrine stimulation of EP4 receptor by PGE2 in pro‐osteoblastic cells.
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Dual Regulation of Alkaline Phosphatase Activity by Calcitonin in Porcine Kidney Cells
TL;DR: Results indicate that calcitonin exerts a dual-regulation of ALP activity in LLC-PK1 cells, positively through the PKA pathway and negatively through PKC.
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Role of Phosphodiesterase 4 Isoenzyme in Alkaline Phosphatase Activation by Calcitonin in Porcine Kidney LLC-PK1 Cells
TL;DR: Calcitonin induces ALP activation through the cyclic AMP-PKA pathway and that PDE 4 isoenzyme is closely associated with the calcitonin-receptor system and plays a major role in hydrolysis of cyclicAMP produced in the kidney tubular cells.
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Postmenopause-like bone loss by mammary carcinoma Walker256/S which secretes luteinizing hormone-releasing hormone.
TL;DR: It seems that the ectopical secretion of LH-RH from the tumor resulted in the decrease in the secretion of gonadotropic hormones, following low level of sex hormones and stopping the estrus cycle, and W256/S-bearing rats may be a model for osteoporosis of hypoovarianism or postmenopause.
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