Shinsuke Yuasa
Keio University
190 Papers
1.4K Citations
Shinsuke Yuasa is an academic researcher from Keio University. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 37, co-authored 161 publications. Previous affiliations of Shinsuke Yuasa include Massachusetts Institute of Technology.
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Papers
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes.
Shugo Tohyama,Fumiyuki Hattori,Motoaki Sano,Takako Hishiki,Yoshiko Nagahata,Tomomi Matsuura,Hisayuki Hashimoto,Tomoyuki Suzuki,Hiromi Yamashita,Yusuke Satoh,Toru Egashira,Tomohisa Seki,Naoto Muraoka,Hiroyuki Yamakawa,Yasuyuki Ohgino,Tomofumi Tanaka,Masatoshi Yoichi,Shinsuke Yuasa,Mitsushige Murata,Makoto Suematsu,Keiichi Fukuda +20 more
TL;DR: A nongenetic method for mass-producing cardiomyocytes from mouse and human PSC derivatives that is based on the marked biochemical differences in glucose and lactate metabolism between cardiomers and noncardiomyocyte and could facilitate progress toward PSC-based cardiac regenerative therapy.
1K
Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells
Tomohisa Seki,Shinsuke Yuasa,Mayumi Oda,Toru Egashira,Kojiro Yae,Dai Kusumoto,Hikari Nakata,Shugo Tohyama,Hisayuki Hashimoto,Masaki Kodaira,Yohei Okada,Hiroyuki Seimiya,Noemi Fusaki,Mamoru Hasegawa,Keiichi Fukuda +14 more
TL;DR: A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both T CR-β and TCR-γ rearrangement by PCR.
606
Nongenetic method for purifying stem cell–derived cardiomyocytes
Fumiyuki Hattori,Hao Chen,Hiromi Yamashita,Shugo Tohyama,Yu Suke Satoh,Shinsuke Yuasa,Weizhen Li,Hiroyuki Yamakawa,Tomofumi Tanaka,Takeshi Onitsuka,Kenichiro Shimoji,Yohei Ohno,Toru Egashira,Ruri Kaneda,Mitsushige Murata,Kyoko Hidaka,Takayuki Morisaki,Erika Sasaki,Takeshi Suzuki,Motoaki Sano,Shinji Makino,Shinzo Oikawa,Keiichi Fukuda +22 more
TL;DR: It is found that a fluorescent dye that labels mitochondria, tetramethylrhodamine methyl ester perchlorate, could be used to selectively mark embryonic and neonatal rat cardiomyocytes, as well as mouse, marmoset and human PSC-derived cardiomers, and that the cells could subsequently be enriched (>99% purity) by fluorescence-activated cell sorting.
441
Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells.
Shinsuke Yuasa,Yuji Itabashi,Uichi Koshimizu,Tomofumi Tanaka,Keijiro Sugimura,Masayoshi Kinoshita,Fumiyuki Hattori,Shin Ichi Fukami,Takuya Shimazaki,Hideyuki Okano,Satoshi Ogawa,Keiichi Fukuda +11 more
TL;DR: While investigating the involvement of BMP signaling in early heart formation in the mouse, it was found that the BMP antagonist Noggin is transiently but strongly expressed in the heart-forming region during gastrulation and acts at the level of induction of mesendoderm to establish conditions conducive to cardiogenesis.
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors
Rie Wada,Naoto Muraoka,Kohei Inagawa,Hiroyuki Yamakawa,Kazutaka Miyamoto,Taketaro Sadahiro,Tomohiko Umei,Ruri Kaneda,Tomoyuki Suzuki,Tomoyuki Suzuki,Kaichiro Kamiya,Shugo Tohyama,Shinsuke Yuasa,Kiyokazu Kokaji,Ryo Aeba,Ryohei Yozu,Hiroyuki Yamagishi,Toshio Kitamura,Keiichi Fukuda,Masaki Ieda +19 more
TL;DR: It is demonstrated that human fibroblasts can be directly converted to iCMs by defined factors, which may facilitate future applications in regenerative medicine.
337