Shinobu Sato
Kyushu Institute of Technology
53 Papers
327 Citations
Shinobu Sato is an academic researcher from Kyushu Institute of Technology. The author has contributed to research in topics: Chemistry & DNA. The author has an hindex of 18, co-authored 43 publications. Previous affiliations of Shinobu Sato include Kyushu University & Takeda Pharmaceutical Company.
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Papers
Electrochemical telomerase assay with ferrocenylnaphthalene diimide as a tetraplex DNA-specific binder.
TL;DR: The telomere sequence could be extended by telomersase with the telomerase substrate primer on the surface of an electrode as proven by an increased current signal of 1 bound to the tetraplex DNA formed on the electrode, the first example of electrochemical detection of telomerases activity without relying on PCR.
79
PCR-free telomerase assay using chronocoulometry coupled with hexaammineruthenium(III) chloride.
Shinobu Sato,Shigeori Takenaka +1 more
TL;DR: An electrochemical method based on chronocoulometry coupled with hexaammineruthenium chloride (RuHex) is proposed for simple and rapid assay of telomerase without relying on PCR and gel electrophoresis, and DNA extended by telomersase in extracts of as small as 5-1,000 HeLa cells on the TS primer-immobilized electrodes was quantified successfully.
44
Linker effect of ferrocenylnaphthalene diimide ligands in the interaction with double stranded DNA
Shinobu Sato,Shigeori Takenaka +1 more
TL;DR: Ferrocenylnaphthalene diimideal ligands as discussed by the authors were synthesized by joining a piperazino or N-methylamino linker with ferrocenecarboxylic, ferroceneacetic, or ferrocnepropionic parts.
41
Design of tetraplex specific ligands: cyclic naphthalene diimide
TL;DR: Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5'-AGGG(TTAGGG)3-3' with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5'-GGG AGG TTT CGC-3’ and 3'-CCC TCC AAA GCG-5' with 0.5 μM of IC50 for telomerase activity.
40
A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative
TL;DR: A cyclic naphthalene diimide (cyclic NDI, 1), carrying a benzene moiety as linker chain, was synthesized and its interaction with G-quadruplex DNAs was studied based on UV-VIS and circular dichroism spectroscopic techniques, thermal melting temperature measurement, and FRET-melting assay.