Shinichi Yachida
Johns Hopkins University
79 Papers
428 Citations
Shinichi Yachida is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 25, co-authored 51 publications. Previous affiliations of Shinichi Yachida include Kagawa University.
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Papers
An integrative epigenomic approach identifies ELF3 as an oncogenic regulator in ASCL1‐positive neuroendocrine carcinoma
Masafumi Horie,Hidenori Tanaka,Masami Suzuki,Yoshihiko Sato,So Takata,Erina Takai,Naoya Miyashita,Akira Saito,Yoichiro Nakatani,Shinichi Yachida +9 more
TL;DR: In this paper , the authors described the epigenomic landscape of GIS-NEC and small cell lung carcinoma (SCLC) by integrating motif enrichment analysis from the assay of transposase-accessible chromatin sequencing (ATAC-seq) and enhancer profiling from a novel cleavage under targets and tagmentation (CUT&Tag) assay for H3K27ac and identified ELF3 as one of the superenhancer-related transcriptional factors in NEC.
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L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
Sho Tabata,Yasushi Kojima,Takeharu Sakamoto,Kaori Igarashi,Kosei Umetsu,Takamasa Ishikawa,Akiyoshi Hirayama,Rie Kajino-Sakamoto,Naoya Sakamoto,Ken Ichi Yasumoto,Keiichi Okano,Yasuyuki Suzuki,Shinichi Yachida,Masahiro Aoki,Tomoyoshi Soga +14 more
TL;DR: In this article , the levels of the L-enantiomer of 2HG (L2HG) were specifically increased in colorectal cancer (CRC) tissues and cell lines.
Mediation effect of intestinal microbiota on the relationship between fiber intake and colorectal cancer
Yoshimitsu Shimomura,Ling Zha,Sho Komukai,Nobuhiro Narii,Tomotaka Sobue,Tetsuhisa Kitamura,Satoshi Shiba,Sayaka Mizutani,Takuji Yamada,Norie Sawada,Shinichi Yachida +10 more
TL;DR: In this paper , the authors conducted a causal mediation analysis to assess the natural indirect effect and natural direct effect of specific intestinal bacteria on association between fiber intake and colorectal cancer risk.
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Oncogenic structural aberration landscape in gastric cancer genomes
Mihoko Saito-Adachi,Natsuko Hama,Yasushi Totoki,Hiromi Nakamura,Yasuhito Arai,Fumie Hosoda,Hirofumi Rokutan,Shinichi Yachida,Mamoru Kato,Akihiko Fukagawa,Tatsuhiro Shibata +10 more
TL;DR: The authors examined 170 GC whole genomes to unravel the oncogenic structural aberration landscape in GC genomes and identify six rearrangement signatures (RSs) which are associated with specific driver events (BRCA1/2 defects, mismatch repair deficiency, and TP53 mutation).