Shinichi Yachida
Johns Hopkins University
79 Papers
428 Citations
Shinichi Yachida is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 25, co-authored 51 publications. Previous affiliations of Shinichi Yachida include Kagawa University.
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Papers
Genetic and Epigenetic Alterations of Familial Pancreatic Cancers
Kieran Brune,Seung-Mo Hong,Ang Li,Shinichi Yachida,Tadayoshi Abe,Margaret Griffith,Dawei Yang,Noriyuki Omura,James R. Eshleman,Marcia I. Canto,Rich Schulick,Alison P. Klein,Ralph H. Hruban,Christine Iacobuzio-Donohue,Michael Goggins +14 more
TL;DR: The prevalence of mutant KRAS2, inactivation of TP53 and SMAD4, and aberrant DNA methylation of a seven-gene panel is similar in familial pancreatic adenocarcinomas as in sporadic pancreatic cancer.
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Clinicopathologic and Genetic Characterization of Traditional Serrated Adenomas of the Colon
Baojin Fu,Shinichi Yachida,Shinichi Yachida,Richard A. Morgan,Yi Zhong,Elizabeth A. Montgomery,Christine A. Iacobuzio-Donahue +6 more
TL;DR: The overall morphologic features of TSA do not correlate with the genetic status of the KRAS and BRAF genes, however, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation.
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Pancreatic thickness as a predictive factor for postoperative pancreatic fistula after distal pancreatectomy using an endopath stapler.
Keiichi Okano,Minoru Oshima,Keitaro Kakinoki,Naoki Yamamoto,Shintaro Akamoto,Shinichi Yachida,Masanobu Hagiike,Hideki Kamada,Tsutomu Masaki,Yasuyuki Suzuki +9 more
TL;DR: Pancreatic thickness is a significant independent risk factor for PF development after distal pancreatectomy with an endopath stapler and theStapler technique is considered to be an appropriate modality in patients with a pancreatic thicknesses of <16 mm.
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Heterogeneity of Pancreatic Cancer Metastases in a Single Patient Revealed by Quantitative Proteomics
Min-Sik Kim,Yi Zhong,Shinichi Yachida,N. V. Rajeshkumar,Melissa L. Abel,Arivusudar Marimuthu,Keshav Mudgal,Ralph H. Hruban,Justin Poling,Jeffrey W. Tyner,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christine A. Iacobuzio-Donahue,Akhilesh Pandey +13 more
TL;DR: The data provide proof-of-principle support that personalized therapy of multiple organ metastases in a single patient should involve the administration of a combination of agents, with each agent targeted to the features of different subclones.
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Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science
TL;DR: Robust experimental and observational research together can provide insights into dynamic interactions between environmental exposures, microbiota, tumour and immunity during carcinogenesis processes, thereby helping to develop precision prevention and therapeutic strategies to ultimately reduce the cancer burden.
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