Shingo Takeda
Showa University
15 Papers
126 Citations
Shingo Takeda is an academic researcher from Showa University. The author has contributed to research in topics: Nucleoside & Thymidine. The author has an hindex of 6, co-authored 15 publications. Previous affiliations of Shingo Takeda include Tohoku Pharmaceutical University.
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Papers
Synthesis of a highly active new anti-HIV agent 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine.
Kazuhiro Haraguchi,Shingo Takeda,Hiromichi Tanaka,Takao Nitanda,Masanori Baba,Ginger E. Dutschman,Yung-Chi Cheng +6 more
TL;DR: The 4'-ethynyl analogue (15) was found to be more potent and less toxic than the parent compound stavudine.
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Novel 4′-Substituted Stavudine Analog with Improved Anti-Human Immunodeficiency Virus Activity and Decreased Cytotoxicity
Ginger E. Dutschman,Susan P. Grill,Elizabeth A. Gullen,Kazuhiro Haraguchi,Shingo Takeda,Hiromichi Tanaka,Masanori Baba,Yung-Chi Cheng +7 more
TL;DR: 4′-ethynyl D4T was found to have a fivefold-better antiviral effect and to cause less cellular and mitochondrial toxicity than D 4T, and should be considered for further development as an anti-HIV drug.
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Lithiation at the 6-position of uridine with lithium hexamethyldisilazide: crucial role of temporary silylation.
TL;DR: Experimental results showed that temporary silylation of O-4 (or N-3) of the uracil ring triggers the C-6 lithiation with LiHMDS, which allowed us to develop an efficient intramolecular alkylation of 5'-deoxy-5'-iodouridine to furnish 6,5'-C-cyclouridine.
15
Synthesis and anti-HIV activity of 4'-cyano-2',3'-didehydro-3'-deoxythymidine.
Kazuhiro Haraguchi,Yoshiharu Itoh,Shingo Takeda,Yosuke Honma,Hiromichi Tanaka,Takao Nitanda,Masanori Baba,Ginger E. Dutschman,Yung-Chi Cheng +8 more
TL;DR: Evaluation of the anti‐HIV activity of 9 showed that this compound is much less potent than the recently reported 2′,3‐didehydro‐3′‐deoxy‐4′‐(ethynyl)thymidine (1).
15
From the Chemistry of Epoxy-Sugar Nucleosides to the Discovery of Anti-HIV Agent 4'-ethynylstavudine-Festinavir
Kazuhiro Haraguchi,Shingo Takeda,Yutaka Kubota,Hiroki Kumamoto,Hiromichi Tanaka,Takayuki Hamasaki,Masanori Baba,Elijah Paintsil,Yung-Chi Cheng +8 more
TL;DR: An anti-HIV agent, 4'-ethynylstavudine (Festinavir) is discovered and it is demonstrated that epoxysugar nucleosides serve as versatile precursor for the stereo-defined synthesis of nucleoside derivatives on the basis of its ring opening with organoaluminum or organosilicon reagents.
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