Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries

Clinical Utility of Intravascular Imaging and Physiology in Coronary Artery Disease

The advent of intravascular imaging has been a significant advancement in visualization of coronary arteries, particularly with optical coherence tomography (OCT) that allows for high-resolution imaging of intraluminal and transmural coronary structures. Accumulating data support a clinical role for OCT in a multitude of clinical scenarios, including assessing the natural history of atherosclerosis and modulating effects of therapies, mechanisms of acute coronary syndromes, mechanistic insights into the effects of novel interventional devices, and optimization of percutaneous coronary intervention. In this state-of-the-art review, we provide an overview of the published data on the clinical utility of OCT, highlighting the areas that need further investigation and the current barriers for further adoption of OCT in interventional cardiology practice.

Intracoronary Optical Coherence Tomography 2018 : Current Status and Future Directions

Accuracy of intravascular ultrasound and optical coherence tomography in identifying functionally significant coronary stenosis according to vessel diameter: A meta-analysis of 2,581 patients and 2,807 lesions.

1. Introducao A Cardiologia Intervencionista tem experimentado extraordinario avanco nos ultimos anos, sendo atualmente o metodo de revascularizacao do miocardio mais empregado em todos os cenarios clinicos, incluindo a doenca arterial coronaria (DAC) estavel e as sindromes coronarias agudas (SCAs). Isso se deve, entre outros fatores, ao grande desenvolvimento tecnologico dos dispositivos percutâneos, a evolucao das tecnicas de tratamento e, principalmente, a expansao das indicacoes, as quais permanecem substanciadas por uma serie de ensaios clinicos comparativos contemporâneos robustos que incluem [...]

Diretriz da sociedade brasileira de cardiologia e da sociedade brasileira de hemodinâmica e cardiologia intervencionista sobre intervenção coronária percutânea

Background: For the identification of functionally significant coronary artery disease, there have not been any dedicated optical coherence tomography (OCT) studies reported previously, although OCT can clearly detect coronary vessel lumina at higher resolution than intravascular ultrasound (IVUS). Methods and Results: OCT and fractional flow reserve (FFR) measurements were performed in 62 intermediate coronary lesions in 59 patients. FFR was calculated as the ratio of distal coronary pressure divided by proximal coronary pressure during maximal hyperemia. FFR 70.0% (sensitivity 96.8%, specificity 83.9%) as the best cutoff values for a FFR <0.75. Conclusions: Anatomical measurements of coronary stenosis obtained by OCT show significant correlation with FFR. OCT has the potential to predict functionally significant stenosis, although the present OCT-derived parameters were smaller than those reported in previous IVUS studies.  (Circ J 2012; 76: 2218–2225)

Optical Coherence Tomography-Derived Anatomical Criteria for Functionally Significant Coronary Stenosis Assessed by Fractional Flow Reserve

Frequency-domain optical coherence tomography (FD-OCT) is a novel technology which provides high-resolution cross-sectional images of coronary arteries. The aim of this study was to evaluate the inter-scan reproducibility of geometric FD-OCT measurements in the clinical setting. We examined 20 coronary lesions using FD-OCT. Following the FD-OCT image acquisition (1st pullback), and after the disengagement and re-engagement of the guiding catheter, an additional acquisition (2nd pullback) was performed using a new FD-OCT catheter. There was excellent correlation for minimum lumen area (r = 0.99, P < 0.001), lesion length (r = 0.99, P < 0.001) and lumen volume (r = 0.99, P < 0.001) between the 1st pullback and the 2nd pullback. The Bland-Altman test demonstrated good agreement between the 1st pullback and the 2nd pullback: the mean difference for minimum lumen area, lesion length, and lumen volume was 0.05 mm(2), 0.03 mm, and 0.70 mm(3), respectively; and the lower and upper limit of agreement for minimum lumen area, lesion length, and lumen volume was -0.58 and 0.48, -0.36 and 0.42, and -13.4 and 12.1, respectively. FD-OCT showed an excellent inter-scan reproducibility for the geometric coronary artery measurements. Our findings emphasize the value of FD-OCT as a tool for clinical longitudinal studies of coronary artery disease.

/pdf/inter-scan-reproducibility-of-geometric-coronary-artery-357mtx2sly.pdf

Inter-Scan Reproducibility of Geometric Coronary Artery Measurements Using Frequency-Domain Optical Coherence Tomography

Aims Vulnerable coronary plaque is characterized by a large lipid core. Although commercially-available optical coherence tomography (OCT) systems use near-infrared light at 1300 nm wavelength, lipid shows characteristic absorption at 1700 nm. Therefore, we developed a novel, short wavelength infra-red, spectroscopic, spectral-domain OCT. The aim of the present study is to evaluate the accuracy of short wavelength (1700 nm) infra-red optical coherence tomography (SWIR-OCT) for identification of lipid tissue within coronary plaques. Methods and results Twenty-three coronary arteries from 10 cadavers were imaged at physiological pressure with 2.7 Fr SWIR-OCT catheter. When a blood-free image was observed, the SWIR-OCT imaging core was withdrawn at a rate of 20 mm/s using an automatic pullback device. SWIR-OCT images were acquired at 94 frames/s and digitally archived. SWIR-OCT generated grey-scale cross sectional images and colour tissue maps of all of the plaque by using a lipid analysis algorithm. After SWIR-OCT imaging, the arteries were pressure-fixed, sliced by cryostat and stained with Oil Red O, and then corresponding histology was collected in matched images. Regions of interest, selected from histology, were 117 lipidic and 34 fibrotic/calcified regions. SWIR-OCT showed high sensitivity (89%) and specificity (92%) for identifying lipid tissue within coronary plaques. The positive predictive value and negative predictive value were 97% and 74%, respectively. Conclusion SWIR-OCT accurately identified lipid tissue in coronary autopsy specimens. This new technique may hold promise for identifying histopathological features of coronary plaque at risk for rupture.

Automated lipid-rich plaque detection with short wavelength infra-red OCT system.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Shingo Ohta

Author Tools

Chat about Author

Papers

Optical Coherence Tomography-Derived Anatomical Criteria for Functionally Significant Coronary Stenosis Assessed by Fractional Flow Reserve

Inter-Scan Reproducibility of Geometric Coronary Artery Measurements Using Frequency-Domain Optical Coherence Tomography

Automated lipid-rich plaque detection with short wavelength infra-red OCT system.