Shiguan Le
4 Papers
Shiguan Le is an academic researcher. The author has contributed to research in topics: Phenotype & Altitude (triangle). The author has co-authored 1 publications.
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Papers
Aldehyde Dehydrogenase 2 Serves as a Key Cardiometabolic Adaptation Regulator in Response to Plateau Hypoxia in Mice.
Rifeng Gao,Kun Yang,Shiguan Le,Hanchuan Chen,Xiaolei Sun,Zhen Dong,Pingjin Gao,Xilu Wang,Jiaran Shi,Ya’nan Qu,Xiang Wei,Kai Hu,Jiucun Wang,Li Jin,Yi Li,Junbo Ge,Aijun Sun +16 more
- 01 Jan 2024
TL;DR: Data reveal ALDH2 acts as a key cardiometabolic adaptation regulator in response to PH, and results showed that ALDH2 attenuated PH-induced impairment of adaptive metabolic programs through 4-HNE/CPT1 signaling, and the CPT1 inhibitor etomoxir significantly ameliorated ALDH2 deficiency-induced cardiac impairment and improved survival in PH mice.
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The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure
Yi Li,Meng Hao,Zixin Hu,Yanyun Ma,Kun Wang,Xiaoyu Liu,Xianhong Yin,Menghan Zhang,Yi Wang,Meng Liang,Yuan Guo,Lei Bao,Shixuan Zhang,Shiguan Le,Chenyuan Wu,Dayan Sun,Yang Wei,Fei Wu,Rui Zhang,Hui Zhang,Shuai Jiang,Xingdong Chen,Xiaofeng Wang,Yao Zhang,Longli Kang,Wenyuan Duan,Bin Qiao,Jiucun Wang,Li Jin +28 more
TL;DR: In this article , the composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure Yi Li 1,3,9,†, Meng Hao 2,4,† and Zixin Hu 2,10,†.
Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation.
Yang Wei,Dayan Sun,Fei Wu,Shixuan Zhang,Bowen Cai,Yanyun Ma,Hongxiang Zheng,Xiangguang Shi,Yi Li,Shiguan Le,Xiang Zhou,Li Jin,Jiucun Wang +12 more
Abstract: Genome-wide studies have identified the nuclear gene EPAS1 and the mitochondrial M9a haplogroup as pivotal contributors to hypoxia adaptation in Tibetans. However, the interaction between these two genetic components is not yet clear. In this study, we demonstrate that cells harboring the Tibetan-specific M9a haplogroup with downregulated EPAS1 (M9a+shEPAS1) exhibit enhanced cellular function under hypoxic conditions. These cells display improved mitochondrial function and proliferation, alongside reduced apoptosis and mtDNA-mediated inflammation, driven by the activation of HIF-1α-BNIP3/NIX-mediated mitophagy and an increase in reactive oxygen species (ROS) levels. Furthermore, treatment with N-acetylcysteine (NAC), PX-478, or Mdivi-1 significantly attenuated BNIP3/NIX-mediated mitophagy, leading to an aggravation of mtDNA-mediated inflammation and apoptosis in M9a+shEPAS1 cells during hypoxia. This study first reveals that ROS-driven HIF-1α-BNIP3/NIX-mediated mitophagy mitigates hypoxia-induced inflammation and apoptosis, contributing to the enhanced hypoxia adaptation observed in Tibetans. HIF-1α-BNIP3/NIX-mediated mitophagy may offer potential therapeutic targets for high-altitude illnesses by regulating cellular energy metabolism and inflammation.
Potential role of hypobaric hypoxia environment in treating pan-cancer
Shixuan Zhang,Xiaoxi Hu,Mengzhen Sun,Xinrui Chen,Shiguan Le,Xilu Wang,Jiucun Wang,Zixin Hu +7 more
TL;DR: This study develops a pan-cancer prognosis model using ADME genes influenced by hypobaric hypoxia, identifying eight genes with prognostic value and potential therapeutic targets, and demonstrating lower risk scores linked to better cancer outcomes.