Shigeyoshi Itohara
RIKEN Brain Science Institute
255 Papers
1.8K Citations
Shigeyoshi Itohara is an academic researcher from RIKEN Brain Science Institute. The author has contributed to research in topics: Biology & Matrix metalloproteinase. The author has an hindex of 85, co-authored 251 publications. Previous affiliations of Shigeyoshi Itohara include Kyoto University & Howard Hughes Medical Institute.
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Papers
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Gabriele Bergers,Rolf A. Brekken,Gerald McMahon,Thiennu H. Vu,Takeshi Itoh,Kazuhiko Tamaki,Kazuhiko Tanzawa,Philip E. Thorpe,Shigeyoshi Itohara,Zena Werb,Douglas Hanahan +10 more
TL;DR: The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.
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Single App knock-in mouse models of Alzheimer's disease
Takashi Saito,Yukio Matsuba,Naomi Mihira,Jiro Takano,Per Nilsson,Shigeyoshi Itohara,Nobuhisa Iwata,Takaomi C. Saido +7 more
TL;DR: In this paper, the authors generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene, and the mice showed typical Aβ pathology, neuroinflammation and memory impairment in an age-dependent manner.
1.1K
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Peter Mombaerts,Alan Richard Clarke,Michael A. Rudnicki,John Iacomini,Shigeyoshi Itohara,Juan J. Lafaille,Lili Wang,Yoshiaki Ichikawa,Rudolf Jaenisch,Martin L. Hooper,Susumu Tonegawa +10 more
TL;DR: Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocyte to CD4+CD8+ thymocytes, as well as for the expansion of the pool ofCD4+ CD8+ cells.
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Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
Itaru Imayoshi,Masayuki Sakamoto,Toshiyuki Ohtsuka,Keizo Takao,Keizo Takao,Tsuyoshi Miyakawa,Tsuyoshi Miyakawa,Masahiro Yamaguchi,Kensaku Mori,Toshio Ikeda,Shigeyoshi Itohara,Ryoichiro Kageyama +11 more
TL;DR: It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.
1.1K
•Journal Article
Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.
Takeshi Itoh,Masatoshi Tanioka,Hiroshi Yoshida,Takayuki Yoshioka,Hirofumi Nishimoto,Shigeyoshi Itohara +5 more
TL;DR: It is indicated that host-derived gelatinase A plays an important role in angiogenesis and tumor progression, suggesting the usefulness of gelatin enzyme A inhibitors for anticancer chemotherapy.
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