Shigeru Nakashima
Gifu University
182 Papers
2.8K Citations
Shigeru Nakashima is an academic researcher from Gifu University. The author has contributed to research in topics: Phospholipase D & Protein kinase C. The author has an hindex of 46, co-authored 182 publications. Previous affiliations of Shigeru Nakashima include Kawasaki Medical School & Hokkaido University.
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Papers
Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death.
Shinichi Yoshimura,Yoshiko Banno,Shigeru Nakashima,Katsuhiko Hayashi,Haruki Yamakawa,Motoshi Sawada,Noboru Sakai,Yoshinori Nozawa +7 more
TL;DR: It is suggested that GSH protects cells from hypoxic injury by direct inhibition of neutral SMase activity and ceramide formation, resulting in inhibition of caspase‐3 activation, and that NAC exerts an additional inhibitory effect(s) downstream of ceramide.
Distinct promoter usage of mdm2 gene in human breast cancer.
Naoki Okumura,Shigehira Saji,Shigehira Saji,Hidetaka Eguchi,Shigeru Nakashima,Shigetoyo Saji,Shin Ichi Hayashi +6 more
TL;DR: Results strongly suggest that other factor(s) is also implicated in the promoter usage of mdm2 gene in human breast cancer tissues.
Hydrogen Peroxide‐Induced Phospholipase D Activation in Rat Pheochromocytoma PC12 Cells: Possible Involvement of Ca2+‐Dependent Protein Tyrosine Kinase
TL;DR: Results suggest that a certain Ca2+‐dependent protein tyrosine kinase(s) somehow participates in H2O2‐induced PLD activation in PC12 cells.
Implication of Ca2+‐Dependent Protein Tyrosine Phosphorylation in Carbachol‐Induced Phospholipase D Activation in Rat Pheochromocytoma PC12 Cells
TL;DR: Results suggest that Ca2+‐dependent protein tyrosine phosphorylation is closely implicated in CCh‐induced PLD activation in PC12 cells.
Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans.
Yoko Sugiyama,Shigeru Nakashima,F. Mirbod,Hiroyuki Kanoh,Yasuo Kitajima,Mahmoud A. Ghannoum,Yoshinori Nozawa +6 more
TL;DR: The present study attempted to clone phospholipase B gene from C. albicans by RT-PCR analysis with degenerate primers based on conserved regions of phospholIPase B from Saccharomyces cerevisiae, Penicillium notatum and Torulaspora delbrueckii and obtained two similar but different cDNA fragments.