Shigeo Horiike
Kyoto Prefectural University of Medicine
174 Papers
1.2K Citations
Shigeo Horiike is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Lymphoma & Chromosomal translocation. The author has an hindex of 28, co-authored 173 publications.
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Papers
•Journal Article
p53 gene mutations and loss of a chromosome 17p in Philadelphia chromosome (Ph1)-positive acute leukemia
Hiroyuki Nakai,Shinichi Misawa,S Tanaka,Hikari Nishigaki,Masafumi Taniwaki,Shouhei Yokota,Shigeo Horiike,Takashima T,Taku Seriu,Hitoshi Nakagawa,Hiroshi Fujii,Chihiro Shimazaki,Hiroshi Okada,Junya Toguchida,Kanji Ishizaki,Tatsuo Abe,Kei Kashima +16 more
TL;DR: P53 gene alterations were commonly involved in Ph1AL with loss of a 17p (two point mutations in three cases), while rarely in cases with normal chromosome 17s (one point mutation in 20 cases and one rearrangement in 13 cases).
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Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene.
Yumiko Kanda-Akano,Kenichi Nomura,Yasuko Fujita,Shigeo Horiike,Kazuhiro Nishida,Masami Nagai,Ikuo Miura,Shigeo Nakamura,Masao Seto,Shinsuke Iida,Ryuzo Ueda,Masafumi Taniwaki +11 more
TL;DR: C-MYC/IGH translocation is possibly an evolutionary alteration following the primary IGH translocation with BCL1, BCL2, or BCL6, and is defined a clinical subset of B-cell lymphoma/leukemia showing extremely poor prognosis.
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Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple Myeloma.
Yuto Fujibayashi,Reiko Isa,Daichi Nishiyama,Natsumi Sakamoto-Inada,Norichika Kawasumi,Junko Yamaguchi,Saeko Kuwahara-Ota,Yayoi Matsumura-Kimoto,Taku Tsukamoto,Yoshiaki Chinen,Yuji Shimura,Tsutomu Kobayashi,Shigeo Horiike,Masafumi Taniwaki,Hiroshi Handa,Junya Kuroda +15 more
TL;DR: It is suggested that enhanced BUB1 expression caused an increase in mitotic segregation errors and the resultant emergence of subclones with altered chromosome numbers and, thus, was involved in CIN in MM.
22
Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia.
Hiroyuki Nakai,Shinichi Misawa,Masafumi Taniwaki,Shigeo Horiike,Takashima T,Taku Seriu,Hitoshi Nakagawa,Hiroshi Fujii,Chihiro Shimazaki,Naoyuki Maruo,Teruaki Akaogi,Naokuni Uike,Tatsuo Abe,Kei Kashima +13 more
TL;DR: The prognostic significance of loss of a 17p emerged when combined with its predominance in the metaphases analysed, and this predominance might easily and rapidly be screened by polymerase chain reaction‐based analysis in about half of the cases.
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