Shigenori Tanaka
University of Tokyo
9 Papers
94 Citations
Shigenori Tanaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Lipopolysaccharide & Triple helix. The author has an hindex of 7, co-authored 9 publications.
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Papers
Augmentation of the Lipopolysaccharide-Neutralizing Activities of Human Cathelicidin CAP18/LL-37-Derived Antimicrobial Peptides by Replacement with Hydrophobic and Cationic Amino Acid Residues
Isao Nagaoka,Satoko Hirota,François Niyonsaba,Michimasa Hirata,Yoshiyuki Adachi,Hiroshi Tamura,Shigenori Tanaka,Didier Heumann +7 more
TL;DR: 18-mer LLKKK is the most potent of the peptide derivatives, with therapeutic potential for gram-negative bacterial endotoxin shock, and the LPS-neutralizing activities of the amphipathic human CAP18/LL-37-derived 18-mer peptide can be augmented by modifying its hydrophobicity and cationicity.
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Inhibition by a CD14 monoclonal antibody of lipopolysaccharide binding to murine macrophages
TL;DR: The results suggest that the 4C1 epitope on murine CD14 plays an important role in LPS binding and is distinct from the rmC5-3 epitope.
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Differential clearance and induction of host responses by various administered or released lipopolysaccharides.
Ryoichi Hasunuma,Hiroyuki Morita,Shigenori Tanaka,Roland Ryll,Marina A. Freudenberg,Chris Galanos,Yoshio Kumazawa +6 more
TL;DR: Results indicate that continuously higher levels of plasma LPS followed by stronger host responses occur during infection and suggest that these differences between LPS-administered and infected mice should be taken into consideration when analyzing host responses induced by LPS.
17
Sulubilized Cell Wall β-Glucan, CSBG, Is an Epitope of Candida Immune Mice
Michiharu Uchiyama,Naohito Ohno,Noriko N. Miura,Yoshiyuki Adachi,Hiroshi Tamura,Shigenori Tanaka,Toshiro Yadomae +6 more
TL;DR: Sera of the Candida immune mice showed higher reactivity than non-immune, normal mice and the reactivity was neutralized by adding soluble CSBG as a competitor, which strongly suggested that CSBG included epitopes of the specific antibody in Candidaimmune mice.
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Enzyme immunoassay system for estimating the ultrastructure of (1,6)-branched (1,3)-β-glucans
Yoshiyuki Adachi,Noriko N. Miura,Naohito Ohno,Hiroshi Tamura,Shigenori Tanaka,Toshiro Yadomae +5 more
TL;DR: A sandwich-type enzyme immunoassay (EIA) system for quantifying branched (1,3)-β-glucans was established in this paper, where a polyclonal antibody was purified with antigen-conjugated aminocellulofine and labelled with biotin to be used as the detection antibody.
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