Shigekazu Nagata
Osaka University
439 Papers
8.3K Citations
Shigekazu Nagata is an academic researcher from Osaka University. The author has contributed to research in topics: Apoptosis & Fas ligand. The author has an hindex of 124, co-authored 428 publications. Previous affiliations of Shigekazu Nagata include Nara Institute of Science and Technology & University of Tokyo.
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Papers
Phospholipid flippases enable precursor B cells to flee engulfment by macrophages
Katsumori Segawa,Yuichi Yanagihashi,Kyoko Yamada,Chigure Suzuki,Yasuo Uchiyama,Shigekazu Nagata +5 more
TL;DR: It is shown that flippases at the plasma membrane are important for quickly internalizing phosphatidylserine (PtdSer) that is exposed by Ca2+-dependent scramblase in activated cells and rescued the lymphopenia in the ATP11C−/y bone marrow.
Correction: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
Masato Enari,Hideki Sakahira,Hideki Yokoyama,Katsuya Okawa,Akihiro Iwamatsu,Shigekazu Nagata +5 more
TL;DR: The open reading frame of the cDNA (pEF-mCAD) consists of 344 amino acids instead of 345 amino acids, and the mature murine CAD is a protein of 342 amino acids with a calculated relative molecular mass of 39,214.18 as discussed by the authors.
Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids
Kirsten Lauber,Kirsten Lauber,Hildegard Keppeler,Luis E. Muñoz,Uwe Koppe,K. Schröder,Hiroshi Yamaguchi,Gerhard Krönke,Stefan Uderhardt,Sebastian Wesselborg,Sebastian Wesselborg,Claus Belka,Shigekazu Nagata,Martin Herrmann +13 more
TL;DR: It is shown that the GC-mediated transactivation of MFG-E8 expression and the concomitantly enhanced elimination of apoptotic cells constitute a novel aspect in this context and renders MFG -E8 a prospective target for future therapeutic interventions in SLE.
Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii.
TL;DR: The Vargula luciferase gene, which contains a signal sequence for secretion, should be well suited as a reporter in studies of gene expression and has significant amino acid sequence homology with an N-terminal segment of the photoprotein aequorin.
Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Hanayo Nakanishi,Tomohiro Nishizawa,Katsumori Segawa,Osamu Nureki,Yoshinori Fujiyoshi,Shigekazu Nagata,Kazuhiro Abe +6 more
TL;DR: Six cryo-EM structures of ATP 11C detail key features of phospholipid translocation by ATP11C, and a common basic mechanism for flippases is emerging.