Shigekazu Nagata

TL;DR: At least three regulatory elements GPE1, GPE2 and GPE3 (G-CSF promoter elements) controlling the gene encoding granulocyte colony-stimulating factor are indispensable for the constitutive expression of the G- CSF gene in human CHU-2 cells and for its lipopolysaccharide(LPS)-inducible expression in macrophages.

TL;DR: It is shown that TRAIL is dispensable for inducing the apoptosis of erythroid cells in DNase II−/− embryos, and therefore, that there is a TRAIL‐independent mechanism for the IFN‐induced apoptosis.

TL;DR: A Fas ligand useful in the medicinal field and a part thereof, a novel DNA coding for the same; an antibody; a recombinant DNA molecule containing the above DNA; a transformant; a method of purifying the novel protein; a process for producing the novel proteins; a novel protein antibody; an oligonucleotide complementary to a Fas l ligand gene; and a method for screening a substance associated with the fas ligand as discussed by the authors.

TL;DR: The application of reversed genetics to phage Qβ and the extension of site-directed mutagenesis to cloned eukaryotic DNA are described.