Shigeaki Ito
Japan Tobacco
20 Papers
63 Citations
Shigeaki Ito is an academic researcher from Japan Tobacco. The author has contributed to research in topics: Sidestream smoke & Proinflammatory cytokine. The author has an hindex of 9, co-authored 20 publications.
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Papers
Oxidative stress responses in human bronchial epithelial cells exposed to cigarette smoke and vapor from tobacco- and nicotine-containing products.
Satoru Munakata,Kanae Ishimori,Nobumasa Kitamura,Shinkichi Ishikawa,Yuichiro Takanami,Shigeaki Ito +5 more
TL;DR: It is found that all endpoints were similarly perturbed by exposure to each AqE, but the effective dose ranges were different between cigarette smoke and the tobacco‐ and nicotine‐containing vapors.
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Ciliatoxicity in human primary bronchiolar epithelial cells after repeated exposure at the air-liquid interface with native mainstream smoke of K3R4F cigarettes with and without charcoal filter.
TL;DR: In cultures exposed to charcoal filtered cigarette smoke, little changes in cilia length were seen after four exposure repetitions, but those effects were reversed after a two day recovery period, indicating that volatile organic compounds, being removed by the charcoal filter tip, affect primary bronchiolar epithelial cells concerning their cilia formation and function comparable with the in vivo situation.
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Structure of novel enzyme in mannan biodegradation process 4-O-β-D-mannosyl-D-glucose phosphorylase MGP.
Setsu Nakae,Shigeaki Ito,Mariko Higa,Takeshi Senoura,Jun Wasaki,Atsushi Hijikata,Masafumi Shionyu,Susumu Ito,Tsuyoshi Shirai +8 more
TL;DR: The crystal structure of a novel component of the mannan biodegradation system, 4-O-β-D-mannosyl- D-glucose phosphorylase (MGP), revealed a unique homohexameric structure, which was formed by using two helices attached to the N- terminus and C-terminus as a tab for sticking between subunits.
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Novel biomarker genes which distinguish between smokers and chronic obstructive pulmonary disease patients with machine learning approach
Kazushi Matsumura,Shigeaki Ito +1 more
TL;DR: The authors' experimental-based transcriptomic analysis identified novel genes associated with COPD, and the 15 genes could distinguish smokers and COPD subjects from non-smokers via machine-learning classification with remarkable accuracy and it is believed it will provide an improved understanding of smoking effects and new insights into COPD.
Application of a direct aerosol exposure system for the assessment of biological effects of cigarette smoke and novel tobacco product vapor on human bronchial epithelial cultures
Shinkichi Ishikawa,Kazushi Matsumura,Nobumasa Kitamura,Kanae Ishimori,Yuichiro Takanami,Shigeaki Ito +5 more
TL;DR: The 3R4F smoke increased cytotoxicity, cytokine secretion, and differential gene expression, depending on the exposure dose, and no changes were detected in any of the analyzed endpoints following NTV vapor exposure, suggesting the biological effects of N TV vapor are lower than those of conventional combustible CS.
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