25 Papers
148 Citations
Shi Chen is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Transplantation & Xenotransplantation. The author has an hindex of 11, co-authored 25 publications. Previous affiliations of Shi Chen include Chinese Ministry of Education.
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Papers
Blockade of Extracellular HMGB1 Suppresses Xenoreactive B Cell Responses and Delays Acute Vascular Xenogeneic Rejection
Jun Li,B. Zhao,X.-H. Zhu,Lin Wang,Huijuan Zou,Shi Chen,Shi Chen,Hui Guo,Hui Guo,Yongle Ruan,Fang Zheng,Fang Zheng,Ying Xiang,Ying Xiang,Changsheng Ming,Changsheng Ming,Feili Gong,Feili Gong,Gang Chen,Gang Chen +19 more
TL;DR: It is shown that neutralization of extracellular HMGB1 can significantly inhibit xenoreactive B cell responses and delay xenograft rejection in a rat‐to‐mouse model of xenotransplantation, uncovering new insights in the role ofHMGB1 in transplantation.
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Cotransplantation with xenogenetic neonatal porcine sertoli cells significantly prolongs islet allograft survival in nonimmunosuppressive rats.
Zhu-zeng Yin,Dong Chen,Feng Hu,Yongle Ruan,Junhua Li,Lu Wang,Ying Xiang,Lin Xie,Ximo Wang,Thomas E. Ichim,Shi Chen,Gang Chen +11 more
TL;DR: The data suggest that xenogeneic Sertoli cells exert a global immune suppressive effect that extends across species barriers in a stringent model of alloimmune rejection and the combination of NPSCs with other immune modulatory regimes may yield novel approaches toward prevention ofallo-islet transplant rejection.
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Improved suppression of circulating complement does not block acute vascular rejection of pig-to-rhesus monkey cardiac transplants.
Gang Chen,Qian-Yun Sun,X.M. Wang,Shiqian Shen,Hui Guo,Hong Wang,Ying Wu,Wan-yu Wang,Yu-liang Xiong,Shi Chen +9 more
TL;DR: It is concluded that repetitive injection of low dose Y‐CVF can be used to continuously suppress circulating complement in a very potent manner and successfully prevent hyperacute rejection (HAR), however, the continuous suppression of circulating complement did not prevent AVR.
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Inhibition of xenogeneic response in porcine endothelium using RNA interference.
Min Zhu,Shu-sen Wang,Zhen-xiong Xia,Rong-hua Cao,Dong Chen,Ya-Bing Huang,Bin Liu,Zhonghua-Klaus Chen,Shi Chen +8 more
TL;DR: These data are the first to demonstrate that RNA interference is a potent tool to down modulate &agr;-Gal expression and to protect endothelial cells from complement-mediated cytotoxicity and to represent a new approach for overcoming hyperacute and acute vascular rejection.
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A study of HLA-G1 protection of porcine endothelial cells against human NK cell cytotoxicity.
S.S. Wang,J.Y. Han,X.W. Wu,R.H. Cao,H.G. Qi,Zhen-xiong Xia,Dong Chen,F.L. Gong,Shi Chen +8 more
- 01 Oct 2004
TL;DR: Results indicate that the expression of HLA-G1 on the porcine cell surface may provide a new approach to overcome NK-mediated immunity to xenografts and directly protect xenogeneic PAECs against attack by human NK cells.
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