Sherry Mou
United States Department of the Army
10 Papers
19 Citations
Sherry Mou is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Virulence & Yersinia pestis. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Sherry Mou include United States Army Medical Research Institute of Infectious Diseases.
Chat about Author
Papers
Genome Sequence of the Deep-Rooted Yersinia pestis Strain Angola Reveals New Insights into the Evolution and Pangenome of the Plague Bacterium
Mark Eppinger,Patricia L. Worsham,Mikeljon P. Nikolich,David R. Riley,Yinong Sebastian,Sherry Mou,Mark Achtman,Luther E. Lindler,Jacques Ravel +8 more
TL;DR: This study sequenced the deep-rooted strain Angola, a virulent Pestoides isolate, and identified numerous novel genetic signatures some of which seem to be intimately associated with plague virulence, which are valuable in the development of a robust typing system critical for forensic, diagnostic, and epidemiological studies.
103
Novel plasmids and resistance phenotypes in Yersinia pestis: unique plasmid inventory of strain Java 9 mediates high levels of arsenic resistance.
Mark Eppinger,Lyndsay Radnedge,Gary L. Andersen,Nicholas J. Vietri,Grant Severson,Sherry Mou,Jacques Ravel,Patricia L. Worsham +7 more
TL;DR: It is demonstrated that Java 9 exhibits high levels of arsenic and arsenite resistance mediated by a novel promiscuous class II transposon, named Tn2503, which was self-transmissible from Java 9 to other Y. pestis strains via conjugation.
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.
Taylor B. Chance,Jennifer Chua,Ronald G. Toothman,Jason T. Ladner,Jonathan E. Nuss,Jo Lynne Raymond,Fabrice Biot,Samandra T. Demons,Lynda Miller,Stephanie Halasohoris,Sherry Mou,G. I. Koroleva,Sean Lovett,Gustavo Palacios,Nicholas J. Vietri,Patricia L. Worsham,Christopher K. Cote,Todd M. Kijek,Joel A. Bozue +18 more
TL;DR: It is demonstrated that the KdsD enzyme is essential for Francisella virulence and may be an attractive therapeutic target for developing novel medical countermeasures.
The D-alanyl-d-alanine carboxypeptidase enzyme is essential for virulence in the Schu S4 strain of Francisella tularensis and a dacD mutant is able to provide protection against a pneumonic challenge.
Todd M. Kijek,Sherry Mou,Beth A. Bachert,Kathleen A. Kuehl,Janice A. Williams,Sharon P. Daye,Patricia L. Worsham,Joel A. Bozue +7 more
TL;DR: Results indicate that the DacD protein of F. tularensis is essential for growth in low pH environments and virulence in vivo, and suggest that a PBP mutant could serve as the basis of a novel, live attenuated vaccine strain.
11
Virulence of Yersinia pseudotuberculosis in Aerosol Models
TL;DR: The range of virulence that was observed among natural isolates of Y. pseudotuberculosis was quite remarkable, which makes it likely that there are multiple independent mechanisms that contribute to pathogenicity by the aerosol route.
5