Sherman E. Ross
6 Papers
79 Citations
Sherman E. Ross is an academic researcher. The author has contributed to research in topics: Receptor & In vivo. The author has an hindex of 4, co-authored 6 publications.
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Papers
Bradykinin Receptor Antagonists Containing N-Substituted Amino Acids: In Vitro and in Vivo B2 and B1 Receptor Antagonist Activity†
Val S. Goodfellow,Manoj V. Marathe,Karen G. Kuhlman,Timothy D. Fitzpatrick,David K. Cuadrado,Wendy L. Hanson,John S. Zuzack,Sherman E. Ross,Maciej Wieczorek,Michael Burkard,Eric T. Whalley +10 more
TL;DR: Very minor structural changes in the N-alkyl amino acid residues in positions 7 and 8 can modify the activity of this class of compounds from being extremely potent antagonists to tight binding partial or full agonists.
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Biochemical Characterization of α-Ketooxadiazole Inhibitors of Elastases
Maciej Wieczorek,Albert Gyorkos,Lyle W. Spruce,Anna Ettinger,Sherman E. Ross,Heather Kroona,Carmen E. Burgos-Lepley,Larry D. Bratton,Tyler S. Drennan,Douglas L. Garnert,Gregory Von Burg,Carolyn G. Pilkington,John C. Cheronis +12 more
TL;DR: Nonpeptidic HNE inhibitors containing the oxadiazole heterocycle displayed promising oral bioavailability and was found to be very effective against PR-3 and PPE.
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Bradykinin antagonists in human systems: Correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum
Maciej Wieczorek,Anna Pilyavskaya,Michael Burkard,John S. Zuzack,Steven W. Jones,Mary Francis,Virginia E. Beckey,Sherman E. Ross,Val S. Goodfellow,Timothy D. Fitzpatrick,Manoj V. Marathe,Albert Gyorkos,Lyle W. Spruce,William M. Selig,John M. Stewart,Lajos Gera,Eric T. Whalley +16 more
TL;DR: The relationship between B2 receptor (soluble and membrane-bound) binding of BK peptidic antagonists, inhibition of calcium signalling at a cellular level, and in vitro inhibition of ileum contraction is examined.
4
Synthesis and evaluation of CE-0266: A new human neutrophil elastase inhibitor
Raymond T. Cunningham,Suzanne E. Mangold,Lyle W. Spruce,Qi-Long Ying,Sanford R. Simon,Maciej Wieczorek,Sherman E. Ross,John C. Cheronis,Gary P. Kirschenheuter +8 more
TL;DR: In this paper, the synthesis and evaluation of 4-(methylsulfinyl)phenyl 2-(1-methyl-2-pyrrolyl)butyrate (CE-0266) and related sulfide and sulfone derivatives, CE-0265 and SE-0267, respectively, are described.
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