28 Papers
49 Citations
Shenglan Li is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 17 publications.
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Papers
Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells
Chen Chen,Peng Jiang,Haipeng Xue,Suzanne E. Peterson,Ha T T Tran,Anna E. McCann,Mana M. Parast,Shenglan Li,David E Pleasure,Louise C. Laurent,Jeanne F. Loring,Ying Liu,Ying Liu,Ying Liu,Wenbin Deng +14 more
TL;DR: Astroglia derived from induced pluripotent stem cells from Down’s syndrome patients impair the development of neurons, and that this can be attenuated with the drug minocycline, which partially corrects the pathological phenotypes of DS astroglia.
piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice
Chunlong Xu,Xiaolan Qi,Xuguang Du,Huiying Zou,Fei Gao,Tao Feng,Hengxing Lu,Shenglan Li,Xiaomeng An,Zhang Lijun,Yuanyuan Wu,Ying Liu,Ning Li,Mario R. Capecchi,Sen Wu +14 more
TL;DR: The results demonstrate that PB is a simple and nonviral choice for efficient in vivo delivery of CRISPR libraries for phenotype-driven screens and identify genes mediating liver tumorigenesis, including known and unknown tumor suppressor genes (TSGs).
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RNA m6A modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability.
Feng Xiong,Ruoyu Wang,Ruoyu Wang,Joo-Hyung Lee,Shenglan Li,Shin-Fu Chen,Zian Liao,Zian Liao,Lana Al Hasani,Lana Al Hasani,Phuoc T. Nguyen,Phuoc T. Nguyen,Xiaoyu Zhu,Joanna Krakowiak,Dung Fang Lee,Leng Han,Kuang-Lei Tsai,Kuang-Lei Tsai,Ying Liu,Ying Liu,Wenbo Li,Wenbo Li +21 more
TL;DR: In this article, N6-methyladenosine (m6A) deposition on nascent RNAs in human cells was profiled by developing a new method MINT-Seq, which revealed that many classes of RTE RNAs, particularly intronic LINE-1s, are strongly methylated.
Signaling pathways in brain tumors and therapeutic interventions
Shenglan Li,Can Wang,Jinyi Chen,Yanjie Lan,Weichunbai Zhang,Z Kang,Yi Zheng,Rong-Jie Zhang,Jianyu Yu,Wenbin Li +9 more
TL;DR: In this paper , the major signaling pathways underlying brain tumor pathogenesis and current progress in therapies, including clinical trials, targeted therapies, immunotherapies, and system therapies, have been systemically reviewed and discussed.
Genetic Modification in Human Pluripotent Stem Cells by Homologous Recombination and CRISPR/Cas9 System
TL;DR: This chapter describes the protocols for making neural lineage reporter lines using homologous recombination and the CRISPR/Cas system-mediated genome editing, including construction of targeting vectors, guide RNAs, transfection into hPSCs, and selection and verification of successfully targeted clones.
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