Sheng Ye
Life Sciences Institute
4 Papers
Sheng Ye is an academic researcher from Life Sciences Institute. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 4, co-authored 4 publications.
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Papers
Src inhibits the Hippo tumor suppressor pathway through tyrosine phosphorylation of Lats1
Yuan Si,Xinyan Ji,Xiaolei Cao,Xiaoming Dai,Lingyi Xu,Hongxia Zhao,Xiaocan Guo,Huan Yan,Haitao Zhang,Chu Zhu,Qi Zhou,Mei Tang,Zongping Xia,Li Li,Yu-Sheng Cong,Sheng Ye,Tingbo Liang,Xin-Hua Feng,Bin Zhao,Bin Zhao +19 more
TL;DR: Findings reveal tyrosine phosphorylation of LATS1 by Src as a novel mechanism of Hippo pathway regulation by cell adhesion and suggest Src activation as an underlying reason for YAP deregulation in tumorigenesis.
Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation
Fansen Meng,Ruyuan Zhou,Shiying Wu,Qian Zhang,Qiuheng Jin,Yao Zhou,Steven W. Plouffe,Shengduo Liu,Hai Song,Zongping Xia,Bin Zhao,Sheng Ye,Xin-Hua Feng,Kun-Liang Guan,Jian Zou,Pinglong Xu +15 more
TL;DR: The identification of Mst1 as a novel physiological negative regulator of IRF3 activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses.
Shengduo Liu,Shasha Chen,Xinran Li,Shiying Wu,Qian Zhang,Qiuheng Jin,Lin Hu,Ruyuan Zhou,Zhengyang Yu,Fansen Meng,Siwen Wang,Yao-Wei Huang,Sheng Ye,Li Shen,Zongping Xia,Jian Zou,Xin-Hua Feng,Pinglong Xu +17 more
TL;DR: The negative regulation of TBK1 via tyrosine phosphorylation and the functional integration of SFKs into innate antiviral immunity are unveiled.
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Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling.
Yi Yu,Yi Yu,Shuchen Gu,Wenjian Li,Chuang Sun,Fenfang Chen,Mu Xiao,Lei Wang,Dewei Xu,Ye Li,Chen Ding,Zongping Xia,Yi Li,Sheng Ye,Pinglong Xu,Bin Zhao,Jun Qin,Ye-Guang Chen,Xia Lin,Xin-Hua Feng,Xin-Hua Feng +20 more
TL;DR: It is shown that Smad7 activates signal transducers and activators of transcription 3 (STAT3) signaling in maintaining mouse embryonic stem cell pluripotency in a manner independent of the TGF-β receptors, yet dependent on the leukemia inhibitory factor (LIF) coreceptor glycoprotein 130 (gp130).