Sheng-Hui Wang
Zhengzhou University
9 Papers
4 Citations
Sheng-Hui Wang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Neddylation & Apoptosis. The author has an hindex of 4, co-authored 9 publications.
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Papers
Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway.
Jian Song,Qiu-Lei Gao,Bo-Wen Wu,Ting Zhu,Xin-Xin Cui,Cheng-Jun Jin,Shu-Yu Wang,Sheng-Hui Wang,Dong-Jun Fu,Hong-Min Liu,Sai-Yang Zhang,Yan-Bing Zhang,Yongchun Li +12 more
TL;DR: Compound F10 was the first to be reported as a new anticancer agent in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway and binding tightly into the colchicine binding site of β-tubulin.
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Progress of tubulin polymerization activity detection methods
TL;DR: In this paper, the biological activity detection methods of tubulin polymerization inhibitors are reviewed and a theoretical basis for the further study and selection of methods for tubulin inhibitors is provided.
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Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents.
Chao-Fan Lu,Sheng-Hui Wang,Xiao-Jing Pang,Ting Zhu,Hong-Li Li,Qing-Rong Li,Qian-Yu Li,Yu-Fan Gu,Zhao-Yang Mu,Min-Jie Jin,Yin-Ru Li,Yang-Yang Hu,Yan-Bing Zhang,Jian Song,Sai-Yang Zhang +14 more
TL;DR: Compound 13e might be a valuable lead compound as antiproliferative agents and amino chalcone derivatives worth further effort to improve amino chAlcone derivatives’ potency.
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Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells.
Jian Song,Xin-Xin Cui,Bo-Wen Wu,Dong Li,Sheng-Hui Wang,Lei Shi,Ting Zhu,Yan-Bing Zhang,Sai-Yang Zhang +8 more
TL;DR: The discovery of a hit scaffold from the in-house library and further structure-based optimizations suggest that 1,2,4-triazine scaffold might provide a novel scaffold for the further development of neddylation inhibitors and compound V11 might be a potential neddyation inhibitor with anticancer activity.
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Discovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells.
Dong-Jun Fu,Xin-Xin Cui,Ting Zhu,Yan-Bing Zhang,Yang-Yang Hu,Li-Rong Zhang,Sheng-Hui Wang,Sai-Yang Zhang +7 more
TL;DR: A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3) as discussed by the authors.
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