Sheng Gu
Los Alamos National Laboratory
22 Papers
342 Citations
Sheng Gu is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Quantitative proteomics & Proteomics. The author has an hindex of 18, co-authored 22 publications. Previous affiliations of Sheng Gu include University of California, Los Angeles & University of North Carolina at Chapel Hill.
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Papers
Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia.
Michael N. Harris,Bulent Ozpolat,Fadi Abdi,Sheng Gu,Allison Legler,Kwasi G. Mawuenyega,Maribel Tirado-Gomez,Gabriel Lopez-Berestein,Xian Chen +8 more
TL;DR: The data in comparison with previous cDNA microarray studies and the reverse transcription-polymerase chain reaction (RT-PCR) experiments demonstrate that broad networks of posttranscriptional suppressive pathways are activated during ATRA-induced growth inhibition processes in APL.
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The Dynamic Alterations of H2AX Complex during DNA Repair Detected by a Proteomic Approach Reveal the Critical Roles of Ca2+/Calmodulin in the Ionizing Radiation-induced Cell Cycle Arrest
Yu Chun Du,Sheng Gu,Jianhong Zhou,Tianyi Wang,Hong Cai,Mark A. MacInnes,E. Morton Bradbury,Xian Chen +7 more
TL;DR: The results suggest that the H2AX complex undergoes dynamic changes upon induction of DNA damage and during DNA repair, and indicates that Ca2+/CaM plays important roles in regulating IR-induced cell cycle arrest, possibly through mediating chromatin structure.
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Flightless I homolog negatively modulates the TLR pathway.
Tianyi Wang,Tsung Hsien Chuang,Tapani Ronni,Sheng Gu,Yu Chun Du,Hong Cai,Hui Qiao Sun,Helen L. Yin,Xian Chen +8 more
TL;DR: Results from immunoprecipitation and a two-hybrid assay indicated that Fliih directly interfered with the formation of the TLR4-MyD88 signaling complex, suggesting a new basis for the regulation of theTLR pathway by FliiH.
Global Investigation of p53-induced Apoptosis Through Quantitative Proteomic Profiling Using Comparative Amino Acid-coded Tagging
Sheng Gu,Zhihe Liu,Songqin Pan,Zeyu Jiang,Huimei Lu,Or Amit,E. Morton Bradbury,E. Morton Bradbury,Chein An A. Hu,Xian Chen +9 more
TL;DR: The broadly identified proteins that are upregulated at the execution stage of the p53-mediated apoptosis are associated with several distinct functional categories: cell cycle arrest and p53 binding, protein chaperoning, plasma membrane dynamics, stress response, antioxidant enzymes, and anaerobic glycolysis.
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Use of deuterium-labeled lysine for efficient protein identification and peptide de novo sequencing.
TL;DR: This technique simplifies the labeling scheme and the interpretation of the MS/MS spectra by assigning different series of fragment ions correctly and easily and is very useful in de novo peptide sequencing.
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