Shen Hsi Yang
University of Manchester
13 Papers
4 Citations
Shen Hsi Yang is an academic researcher from University of Manchester. The author has contributed to research in topics: Transcription factor & SUMO protein. The author has an hindex of 10, co-authored 13 publications.
Chat about Author
Papers
Transcriptional regulation by the MAP kinase signaling cascades
TL;DR: The current knowledge of MAPK-mediated gene regulation is summarized, and how complexities in signaling outcomes are achieved and how this relates to physiological processes are focused on.
518
An extended consensus motif enhances the specificity of substrate modification by SUMO
TL;DR: The roles of clusters of acidic residues located downstream from the core SUMO modification sites in proteins such as the transcription factor Elk‐1 are probed and it is demonstrated that these are functionally important in SUMO‐dependent transcriptional repression of Elk-1 transcriptional activity.
PIASx acts as an Elk‐1 coactivator by facilitating derepression
TL;DR: The data reveal a novel coactivator function for PIASxα through reversing SUMO‐mediated repression of transcription factor activity, a key event in the activation of Elk‐1 in response to signalling through the ERK MAP kinase pathway.
Convergence of the SUMO and MAPK pathways on the ETS-domain transcription factor Elk-1.
TL;DR: The molecular events underlying changes in Elk-1 status, and the role of PIASxalpha [protein inhibitor of activated STAT (signal transducer and activator of transcription) xalpha] as a co-activator that facilitates this process, are discussed.
49
PIASxα Differentially Regulates the Amplitudes of Transcriptional Responses Following Activation of the ERK and p38 MAPK Pathways
TL;DR: P38 MAP kinase-mediated PIASxalpha phosphorylation acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated.
45