Sheetal Singh
University of California, Davis
10 Papers
85 Citations
Sheetal Singh is an academic researcher from University of California, Davis. The author has contributed to research in topics: DNA & Histone. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Sheetal Singh include United States Department of Veterans Affairs.
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Papers
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.
Hongan Le,Sheetal Singh,Shyh Jen Shih,Nga Du,Sabine Schnyder,Grace A. Loredo,Christine Bien,Laura C. Michaelis,Amir A. Toor,Manuel O. Diaz,Andrew T M Vaughan,Andrew T M Vaughan +11 more
TL;DR: A model whereby Topoisomerase II facilitates the organization of nuclease‐sensitive secondary structures, stabilized by palindrome association, which are prone to rearrangement is proposed, which is based on data from breast cancer and lymphoma patients receiving Topoisomersase II inhibitor therapy.
Impaired NHEJ function in multiple myeloma.
TL;DR: In this paper, ionizing radiation was used to induce DNA double strand breaks in three MM cell lines, and the ability of protein extracts to support in vitro DNA repair was measured, concluding that suppression of aberrant NHEJ function using the DNA-PK inhibitor NU7026 may facilitate access of DNA ends to an intact homologous recombination repair pathway paradoxically increasing survival after irradiation.
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Estrogen treatment induces MLL aberrations in human lymphoblastoid cells
Sabine Schnyder,Nga Du,Hongan B. Le,Sheetal Singh,Grace A. Loredo,Grace A. Loredo,Andrew T M Vaughan,Andrew T M Vaughan +7 more
TL;DR: Concentrations of E2 and 4-OH-E2 that may occur during pregnancy, or during use of oral contraceptives, can cause aberrations of the MLL gene and could be a factor in the early events of leukemogenesis occurring in utero.
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Localized DNA cleavage secondary to genotoxic exposure adjacent to an Alu inverted repeat.
TL;DR: A region of common LOH telomeric termination at 11q24 was observed in clones of H292 mucoepidermoid cells established after irradiation (IR), notable for both DNAse hypersensitivity and an open chromatin conformation inferred from histone modification data.
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Suberoylanilide Hydroxyamic Acid Modification of Chromatin Architecture Affects DNA Break Formation and Repair
TL;DR: SAHA shows efficacy as a radiosensitizer at clinically obtainable levels in its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access.
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