Sheena M. Cruickshank
Manchester Academic Health Science Centre
67 Papers
247 Citations
Sheena M. Cruickshank is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 26, co-authored 63 publications. Previous affiliations of Sheena M. Cruickshank include University of London & University of Leeds.
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Papers
Cutaneous Nod2 expression regulates the skin microbiome and wound healing in a murine model
Helen L. Williams,Rachel A. Crompton,Helen A. Thomason,Laura Campbell,Gurdeep Singh,Andrew J. McBain,Sheena M. Cruickshank,Matthew J. Hardman +7 more
TL;DR: The importance of the microbial communities in skin wound healing outcome is shown, with high-throughput sequencing and quantitative real-time PCR showing a significant compositional shift in the genus Pseudomonas in Nod2–/– mice.
Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis
Joy Carmelina Indira Singh,Sheena M. Cruickshank,Darren J. Newton,Louise Wakenshaw,A Graham,Jinggang Lan,Jeremy Peter Alan Lodge,Peter J. Felsburg,Simon R. Carding +8 more
TL;DR: Findings identify changes in TLR expression and signaling during the development of colitis that may contribute to changes in the host response to bacterial antigens seen in colitis.
Five-Year Follow-Up on the Prevalence and Intensity of Infections of Schistosoma mansoni in a Hard-to-Reach District of Madagascar.
Stephen A. Spencer,Stephen A. Spencer,Cortland Linder,James M StJ Penney,Hannah J Russell,Kate Hyde,Caitlin Sheehy,Alice Reid,Emmanuel H Andriamasy,Emmanuel H Andriamasy,Gina U. Raderalazasoa,Daniel A L Rakotomampianina,Anjara Mihaja Nandimbiniaina,Tahiry N. Ranaivoson,Antsa Andrianiaina,Sheena M. Cruickshank,Amaya L. Bustinduy,J Russell Stothard,Glenn T. Edosoa,Alain M. Rahetilahy +19 more
TL;DR: Despite reductions in infection prevalence and intensity, schistosomiasis still poses a significant public health challenge in Marolambo district and twice yearly MDA cycles and/or community-wide MDA are suggested to better reduce infections.
Functional characterization of T cells in abdominal aortic aneurysms.
TL;DR: The composition of the AAA inflammatory infiltrate was remarkably consistent, and when re‐stimulated ex‐vivo T cells produced a stereotypical cytokine response, consistent with the hypothesis that AAA T cells can promote tissue inflammation by secretion of proinflammatory cytokines, and in addition provide signals for B‐cell help.
Intraepithelial γδ+ Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection
Jane E. Dalton,Sheena M. Cruickshank,Charlotte E. Egan,Rainy Mears,Darren J. Newton,Elizabeth M. Andrew,Beth Lawrence,Gareth J. Howell,Kathryn J. Else,Marc-Jan Gubbels,Boris Striepen,Judith E. Smith,Stanley J. White,Simon R. Carding +13 more
TL;DR: A novel role is identified for γδ + iIELs in maintaining TJ integrity and epithelial barrier function that have implications for understanding the pathogenesis of intestinal inflammatory diseases associated with disruption of TJ complexes.