Sheeba Rani Manikonda
Indian Institute of Chemical Technology
4 Papers
18 Citations
Sheeba Rani Manikonda is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Chemical synthesis & Catalysis. The author has an hindex of 3, co-authored 4 publications.
Chat about Author
Papers
Chemoenzymatic synthesis with lipase catalyzed resolution and evaluation of antitumor activity of (R/S)-2-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H-pyrrolo[3,4-b]quinolin-3(2H)-one.
TL;DR: Newly synthesized and resolved compounds were screened for their antitumor activity against cancer cells such as human neuroblastoma SK-N-SH and human lung carcinoma A549 cell line in vitro and showed that the compound 1 S-(-) alcohol was more effective in inhibiting the tumor cell growth.
48
Lewis acid-assisted olefin cross-metathesis reaction: an efficient approach for the synthesis of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin and evaluation of their antitumor activity
Lingaiah Nagarapu,Hanmant K. Gaikwad,Rajashaker Bantu,Sheeba Rani Manikonda,C. Ganesh Kumar,Sujitha Pombala +5 more
TL;DR: A series of glycosidic-pyrroloquinolinone based novel building blocks of camptothecin (2a - g ) were synthesized via Lewis acid-assisted olefin cross-metathesis reaction using Ti(O i Pr) 4 30
9
Synthesis of novel building blocks of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one and evaluation of their antitumor activity
Lingaiah Nagarapua,Hanmant K. Gaikwad,Sheeba Rani Manikonda,Rajashaker Bantu,Krishna Madhuri Manda,Shasi V. Kalivendi +5 more
TL;DR: A series of new building blocks consisting of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one with potential as selective antitumor agents is described, and most of these compounds were effective in inhibiting neuroblastoma cell growth.
8
Chemoenzymatic Synthesis with Lipase Catalyzed Resolution and Evaluation of Antitumor Activity of (R/S)-2-[2-Hydroxy-3-(4-phenylpiperazin-1-yl)propyl]-1H-pyrrolo [3,4-b]quinolin-3(2H)-one.
TL;DR: The compounds (+)-(III and (-)-(I) were screened for their antitumor activity against the human neuroblastoma SK-N-SH and human lung carcinoma A549 cell lines in vitro as discussed by the authors.
4