Sharyl L. Wong
Harvard University
9 Papers
Sharyl L. Wong is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Sharyl L. Wong include University of California, San Francisco.
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Papers
Towards a proteome-scale map of the human protein–protein interaction network
Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.
3.2K
Global Mapping of the Yeast Genetic Interaction Network
Amy Hin Yan Tong,Guillaume Lesage,Gary D. Bader,Huiming Ding,Hong Xu,Xiaofeng Xin,James D. Young,Gabriel F. Berriz,Renee L. Brost,Michael Chang,Yiqun Chen,Xin Cheng,Gordon Chua,Helena Friesen,Debra S. Goldberg,Jennifer Haynes,Christine Humphries,Grace He,Shamiza Hussein,Lizhu Ke,Nevan J. Krogan,Zhijian Li,Joshua N. Levinson,Hong Lu,Patrice Menard,Christella Munyana,Ainslie B. Parsons,Owen Ryan,Raffi Tonikian,Tania Michelle Roberts,Anne-Marie Sdicu,Jesse Shapiro,Bilal N. Sheikh,Bernhard Suter,Sharyl L. Wong,Lan V. Zhang,Hongwei Zhu,Christopher G. Burd,Sean Munro,Chris Sander,Jasper Rine,Jack Greenblatt,Matthias Peter,Anthony Bretscher,Graham Bell,Frederick P. Roth,Grant W. Brown,Brenda J. Andrews,Howard Bussey,Charles Boone +49 more
TL;DR: Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
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A Map of the Interactome Network of the Metazoan C. elegans
Siming Li,Christopher M. Armstrong,Nicolas Bertin,Hui Ge,Stuart Milstein,Mike Boxem,Pierre-Olivier Vidalain,Jing-Dong J. Han,Alban Chesneau,Tong Hao,Debra S. Goldberg,Ning Li,Monica Martinez,Jean François Rual,Philippe Lamesch,Lai Xu,Lai Xu,Muneesh Tewari,Sharyl L. Wong,Lan V. Zhang,Gabriel F. Berriz,Laurent Jacotot,Philippe Vaglio,Jérôme Reboul,Tomoko Hirozane-Kishikawa,Qian-Ru Li,Harrison W. Gabel,Ahmed Elewa,Ahmed Elewa,Bridget L. Baumgartner,Debra J. Rose,Haiyuan Yu,Stephanie Bosak,Reynaldo Sequerra,Andrew G. Fraser,Susan E. Mango,William M. Saxton,Susan Strome,Sander van den Heuvel,Fabio Piano,Jean Vandenhaute,Claude Sardet,Mark Gerstein,Lynn Doucette-Stamm,Kristin C. Gunsalus,J. Wade Harper,J. Wade Harper,Michael E. Cusick,Frederick P. Roth,David E. Hill,Marc Vidal +50 more
TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.
Combining biological networks to predict genetic interactions.
Sharyl L. Wong,Lan V. Zhang,Amy Hin Yan Tong,Zhijian Li,Debra S. Goldberg,Oliver D. King,Guillaume Lesage,Marc Vidal,Brenda J. Andrews,Howard Bussey,Charles Boone,Frederick P. Roth +11 more
TL;DR: Experimental evidence demonstrated the reliability of the predicted pairs of SSL genes in Saccharomyces cerevisiae by using probabilistic decision trees to integrate multiple types of data, including localization, mRNA expression, physical interaction, protein function, and characteristics of network topology.
Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network
Lan V. Zhang,Oliver D. King,Sharyl L. Wong,Debra S. Goldberg,Amy Hin Yan Tong,Guillaume Lesage,Brenda J. Andrews,Howard Bussey,Charles Boone,Frederick P. Roth +9 more
TL;DR: An integrated Saccharomyces cerevisiae interaction network is assembled in which nodes represent genes (or their protein products) and differently colored links represent the aforementioned five biological interaction types and it is shown that most of the motifs form 'network themes' – classes of higher-order recurring interconnection patterns that encompass multiple occurrences of network motifs.