Sharon Primeaux
6 Papers
1 Citations
Sharon Primeaux is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 6 publications.
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Papers
Metabolic modulation of synaptic failure and thalamocortical hypersynchronization with preserved consciousness in Glut1 deficiency
Karthik Rajasekaran,Qian Ma,Levi B. Good,Gauri Kathote,Vikram Jakkamsetti,Peiying Liu,Adrian Avila,Sharon Primeaux,Julio Enciso Alva,Kia H. Markussen,Isaac Marin-Valencia,Deepa Sirsi,Peter M. S. Hacker,Matthew S. Gentry,Jianzhong Su,Hanzhang Lu,Juan M. Pascual +16 more
TL;DR: Electroencephalography in G1D individuals revealed nutrition time-dependent seizure oscillations often associated with preserved volition despite electrographic generalization and uniform average oscillation duration and periodicity, suggesting increased facilitation of an underlying neural loop circuit.
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Maximum dose, safety, tolerability and ketonemia after triheptanoin in glucose transporter type 1 deficiency (G1D)
I. Malaga,Adrian Avila,Sharon Primeaux,Raja Reddy Kallem,Charles R. Roe,William C. Putnam,Jason Y. Park,Shlomo Shinnar,Chul-Woo Ahn,Juan M. Pascual +9 more
TL;DR: In this paper , a 3 + 3 dose-finding approach was used to establish a maximum, potentially greater dose of triheptanoin for Glucose transporter type 1 deficiency encephalopathy (G1D).
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Combination of triheptanoin with the ketogenic diet in Glucose transporter type 1 deficiency (G1D)
Adrian Avila,Deepa Sirsi,Saima N Kayani,Sharon Primeaux,Gauri Kathote,Vikram Jakkamsetti,Raja Reddy Kallem,William C. Putnam,Jason Y. Park,Shlomo Shinnar,Juan M. Pascual +10 more
TL;DR: In this paper , the compatibility of triheptanoin at maximum tolerable dose with the ketogenic diet was examined in 10 Glucose transporter type 1 deficiency (G1D) individuals using clinical and electroencephalographic analyses, glycemia, and four and five-carbon ketosis.
Machine-learning Assisted Differentiation Between Physiological Oscillation Epochs and Muscle or Epileptiform activity in EEGs (S30.005)
Vikram Jakkamsetti,Gauri Kathote,Adrian Avila,Sharon Primeaux,Aksharkumar Dobariya,Ignacio Málaga-Diéguez,Juan M. Pascual +6 more
- 25 Apr 2023
TL;DR: Pascual et al. as discussed by the authors used an instantaneous wavelet scalogram to generate a representative frequency waveform for an event and analyzed using action potential waveform sorting Wave clus.
Red blood cells as glucose carriers to the human brain: Modulation of cerebral activity by erythrocyte exchange transfusion in Glut1 deficiency (G1D)
Richard C. Wang,Eunice E. Lee,N. De Simone,Gauri Kathote,Sharon Primeaux,Adrian Avila,Dong-Min Yu,Mark D. Johnson,Levi B. Good,Vikram Jakkamsetti,Ravindra Sarode,Alice Ann Holland,Juan M. Pascual +12 more
TL;DR: In this article , the authors proposed a nearly direct pathway for metabolic substrate transfer to neural cells that complements the better characterized plasma to endothelium transfer, which was further substantiated by in vitro measurement of direct erythrocyte to endothelial cell glucose flux.