The advent of well-defined catalysts for olefin metathesis which combine high activity, durability, and excellent tolerance towards polar functional groups has revolutionized the field. The past decade has seen the rapid embrace of these reagents as tools for advanced organic and polymer chemistry and the success of this development is witnessed by a plethora of elegant applications to the synthesis of natural and nonnatural products. This review article provides an overview of these developments and intends to familiarize the reader with some very recent advances which hold the promise to expand the scope of the reaction even further. Moreover, the positive impact of metathesis on the fundamental logic of retrosynthetic planning is demonstrated by means of typical examples. Finally, it will be shown that metathesis is by no means restricted to alkenes as substrates, and some comments on metathesis reactions following unconventional mechanistic pathways will also be presented.

Olefin Metathesis and Beyond

The changing face of ciguatera

Anti–cancer Nano drugs separation is investigated as one of the most important steps of a process. An important technique of anti–cancer Nano drugs separation is by means of supercritical fluids. Fluids such as Ozone (O 3 ) show an increase in their solubility when they enter the zone of supercritical condition. The application of supercritical fluids is preferred in the separation of anti–cancer Nano drugs whose sensitivity to temperature and pressure are high–Nano materials such as drugs, foods, proteins and so on. The molecular shape of these Nano compounds would be transformed when these parameters change. In the current editorial, firstly, a new third equation of state has been presented with the combination of Soave’s defending statement and Redlich–Kwong’s attracting statement, then and according to the six well–defined scales, the solubility of anti–cancer Nano drugs in the supercritical fluid of Ozone (O 3 ) has been studied with the aid of new equations and also its results have been compared with the results of Soave–Redlich–Kwong (SRK) and Pang–Robinson (PR) equations. In addition, the error of solubility for 196 experimental points in the new equation of state, Soave–Redlich–Kwong (SRK) and Pang–Robinson (PR) equations are 7.352%, 11.728% and 9.294%, respectively. It indicates that the new equation possesses an acceptable and reasonable accuracy and precision in the prediction of solubility.

/pdf/nitrogen-oxygen-phosphorus-and-sulphur-heterocyclicanti-3t9qqje6pw.pdf

Nitrogen, Oxygen, Phosphorus and Sulphur HeterocyclicAnti Cancer Nano Drugs Separation in the Supercritical Fluidof Ozone (O3) Using Soave Redlich Kwong (SRK) and Pang Robinson (PR) Equations

Covering: 1 April 1998 to 30 June 1999. Previous review: J. Chem. Soc., Perkin Trans. 1, 1998, 4175.

Saturated oxygen heterocycles

A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C

A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C.

Reactions of 3-(3′,4′,6′-tri- O -benzyl-β- d -glucopyranosyl)propene with H 2 /CO in the presence of rhodium catalysts can give high yields of a linear aldehyde which can be further modified to give fused 6,7-oxygen heterocyclic compounds. These are useful as intermediates in the synthesis of cyclic polyethers, e.g., the marine toxin, ciguatoxin CTX1. Almost complete regioselectivity for the linear aldehyde was obtained using the bulky bidentate diphosphite ligand, BIPHEPHOS.

Carbonylation approaches to oxygen heterocyclic compounds

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A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C

A Short Synthesis of the A/B Ring Systems of the Pacific Ciguatoxins P-CTX-3C and Dihydroxy-P-CTX-3C.

Carbonylation approaches to oxygen heterocyclic compounds