Sharon E. Bickel
Dartmouth College
24 Papers
249 Citations
Sharon E. Bickel is an academic researcher from Dartmouth College. The author has contributed to research in topics: Chromosome segregation & Establishment of sister chromatid cohesion. The author has an hindex of 17, co-authored 24 publications. Previous affiliations of Sharon E. Bickel include Massachusetts Institute of Technology.
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Papers
Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein.
TL;DR: It appears that MEI-S332 assembles into a multimeric protein complex that localizes to centromeric regions during prometaphase and is required for the maintenance of sister-chromatid cohesion until anaphase, rather than its establishment in S phase.
Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.
TL;DR: It is found that inducing oxidative stress in Drosophila oocytes during meiotic prophase causes a significant increase in segregation errors due to premature loss of cohesion, and this data demonstrate that oxidative stress during the stage at which human oocytes remain arrested for decades can cause meiotic segregation errors and offer insight into why cohesion deteriorates with age.
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The cohesion protein ORD is required for homologue bias during meiotic recombination
TL;DR: It is concluded that ORD activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, thereby promoting homologue bias during meiotic recombination in Drosophila.
Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced.
TL;DR: The findings that recombinant chromosomes are at highest risk for loss of chiasmata during diplotene argue that human oocytes are most vulnerable to age-induced loss of meiotic cohesion at the stage at which they remain arrested for several years.
Regulation of meiotic cohesion and chromosome core morphogenesis during pachytene in Drosophila oocytes.
TL;DR: This work presents a model for how chromosome cores are assembled during Drosophila meiosis and the role of ORD in meiotic cohesion, chromosome core maintenance and homologous recombination and reveals that the α-kleisin C(2)M is required for the assembly of chromosome cores during pachytene but is not involved in recruitment of cohesin SMCs to the centromeres.