Sharon Chadwick
National Institutes of Health
4 Papers
128 Citations
Sharon Chadwick is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cystic fibrosis & Milrinone. The author has an hindex of 4, co-authored 4 publications.
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Papers
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.
Eric W.F.W. Alton,M Stern,Raymond Farley,Adam Jaffe,Sharon Chadwick,J. Phillips,Jane C. Davies,Stephen N. Smith,JE Browning,Michael G. Davies,Margaret E. Hodson,Stephen R. Durham,D. Li,Peter K. Jeffery,M. Scallan,RP Balfour,Simon J. Eastman,Seng H. Cheng,Alan E. Smith,D. P. Meeker,Duncan M. Geddes +20 more
TL;DR: The safety and efficacy of cationic-lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis was studied in a double-blind placebo-controlled trial.
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Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers.
Sharon Chadwick,HD Kingston,M Stern,RM Cook,BJ O’Connor,M Lukasson,RP Balfour,M Rosenberg,S H Cheng,Alan E. Smith,D. P. Meeker,Duncan M. Geddes,Ewfw Alton +12 more
TL;DR: It is suggested that a single application of aerosol formulation of GL-67A does not result in clinically detectable changes when given by nebulisation into the lungs of normal volunteers and provides an indication of a lipid dose tolerated in man.
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The In Vivo Effects of Milrinone on the Airways of Cystic Fibrosis Mice and Human Subjects
Stephen N. Smith,Peter G. Middleton,Sharon Chadwick,Adam Jaffe,Katy A. Bush,Sarah Rolleston,Ray Farley,Stephen Delaney,Brandon J. Wainwright,Duncan M. Geddes,Eric W.F.W. Alton +10 more
TL;DR: The use of milrinone to induce chloride secretion in CF airways in vivo does not support the use of this agent in vivo.
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Potential Difference Measurements in the Lower Airway of Children with and without Cystic Fibrosis
Jane C. Davies,Michael J. Davies,Donna McShane,Stephen M. Smith,Sharon Chadwick,Adam Jaffe,Raymond Farley,Louise Collins,Andrew Bush,Michael Scallon,John Pepper,Duncan M. Geddes,Eric W.F.W. Alton +12 more
TL;DR: A small, single-lumen catheter technique is reported allowing baseline potential difference and chloride secretion to be assessed in the distal airways of children as young as 1 year of age, confirming that invasive bronchoscopic techniques can be performed safely and reliably in small children.
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