Shaoxiao Wang
LSU Health Sciences Center Shreveport
10 Papers
48 Citations
Shaoxiao Wang is an academic researcher from LSU Health Sciences Center Shreveport. The author has contributed to research in topics: Endoplasmic reticulum & Triclabendazole. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Shaoxiao Wang include Louisiana State University.
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Papers
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.
Shaoxiao Wang,Siyuan Zhang,Liang-Chun Liou,Qun Ren,Zhaojie Zhang,Guy A. Caldwell,Kim A. Caldwell,Stephan N. Witt +7 more
TL;DR: This finding suggests that ETA exerts its protective effect by boosting PE through the Kennedy pathway and fails to rescue this degeneration in worms that undergo double RNAi depletion of phosphatidylserine decarboxylase and choline/ETA phosphotransferase.
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Novel suppressors of α-synuclein toxicity identified using yeast
Jun Liang,Cheryl Clark-Dixon,Shaoxiao Wang,Todd R. Flower,Tara Williams-Hart,Richard M. Zweig,Lucy C. Robinson,Kelly Tatchell,Stephan N. Witt +8 more
TL;DR: Four of the five genes are specific for α-syn in that they fail to protect cells from the toxicity of the two inherited mutants A30P or A53T, which suggests that α- syn causes toxicity to cells through a different pathway than these two inherit mutants.
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Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease
TL;DR: Inhibitors of ceramide synthesis, myriocin and FB1, were extremely toxic to wild-type yeast cells expressing (WT, A53T, or E46K) α-syn but much less toxic to cells expressing A30P.
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.
Shaoxiao Wang,Baoshan Xu,Liang-Chun Liou,Qun Ren,Shile Huang,Yan Luo,Zhaojie Zhang,Stephan N. Witt +7 more
TL;DR: It is shown that aSyn disrupts mitogen-activated protein kinase (MAPK)-controlled stress signaling in yeast and human cells, which results in inefficient cell protective responses and cell death.
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Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast
Xianpeng Liu,Yong Joo Lee,Liang-Chun Liou,Qun Ren,Zhaojie Zhang,Shaoxiao Wang,Stephan N. Witt +6 more
TL;DR: Low levels of alpha-synuclein (α-syn) protect S. cerevisiae cells from the growth inhibition and reactive oxygen species (ROS) accumulation induced by HU, and when residues 2-10 or 96-140 are deleted, this protective function of α-syn in the nucleus is abolished.