Shaoshi Chen
5 Papers
Shaoshi Chen is an academic researcher. The author has contributed to research in topics: Medicine & Cross-sectional study. The author has co-authored 2 publications.
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Papers
Induction chemotherapy-based organ-preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer-Results of a matched-pair analysis.
Yifan Yang,Lifeng Feng,Qi Zhong,Yang Zhang,Zhigang Huang,Shurong Zhang,Shuling Li,Junmao Gao,Lizhen Hou,Hongzhi Ma,Shizhi He,Qian Shi,Meng Lian,Yanmin Shao,Xixi Shen,Jiaming Chen,Lingwa Wang,Haiyang Li,Shaoshi Chen,Jiaqi Xu,Ru Wang,Jugao Fang +21 more
TL;DR: In this paper , the authors performed a paired analysis to compare the therapeutic effect between the induction chemotherapy-based organ-preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total LCT.
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PPARG and the PTEN-PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma
Boxuan Han,Jiaming Chen,Shaoshi Chen,Xixi Shen,Lizhen Hou,Meng Lian +5 more
TL;DR: PPARG and the PTEN-PI3K/AKT signaling axis may cofunction in promoting chemosensitivity in hypopharyngeal squamous cell carcinoma, influencing chemosensitivity through the regulation of AKT and PTEN expression.
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Fabrication of hyaluronic acid-altered gold complex delivery for head and neck squamous cell carcinoma therapy with high antitumor efficacy and low in vivo toxicity
Shizhi He,Jiaming Chen,Yanming Zhao,Ru Wang,Yurong He,Shaoshi Chen,Yifan Yang,Changyu Zhu,Jingyang Zhao,Jugao Fang +9 more
- 01 Mar 2024
TL;DR: Researchers developed a nanomedicine (HA/Au-PDA@CZT) that targets head and neck squamous cell carcinoma with high efficacy and low toxicity, utilizing pH and NIR dual stimuli, and synergistic chemo-photothermal therapy.
M2 Macrophage exosomal HOXC13-AS in laryngeal cancer immunity via targeting miR-485-5p/IGF2BP2/PD-L1.
Yurong He,Siyu Zhu,Ru Wang,Shaokun Liu,Xixi Shen,Xinyu Li,Shaoshi Chen,Jugao Fang +7 more
Abstract: This study investigates the role of M2-exo-mediated HOXC13-AS in laryngeal squamous cell carcinoma (LSCC) by examining its transmission to tumor microenvironment (TME) macrophages. Exosomes from M2 macrophages were isolated and characterized using transmission electron microscopy, nanoparticle tracer analysis and western blot. Expression of HOXC13-AS, miR-485-5p, IGF2BP2, and PD-L1 was analyzed. Different interventions on LSCC cell function and immune escape were detected using molecular biological techniques. The study found that elevated HOXC13-AS were present in LSCC, and M2-exo expression was significantly increased in LSCC cells. Silencing HOXC13-AS in M2-exo inhibited LSCC malignant progression and immune escape in vivo and in vitro. M2-exo-mediated HOXC13-AS also regulated IGF2BP2 expression, impacting cellular biological function and immune escape process. The study concludes that M2-exo-mediated HOXC13-AS promotes LSCC malignancy and immune escape.
Effect of Traumatic Upper-Limb Injury on Cognitive Functions: A Cross-Sectional Observational Study.
Xue Zhang,Tamara Tse,Shaoshi Chen,Xia Li,Maryam Zoghi +4 more
TL;DR: In this article , the authors explored the association between cognitive function and traumatic upper-limb injury and found that traumatic upper limb injury can impact short-term memory, which should be kept in mind during rehabilitation.