Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and complexity of in vivo tumors. This approach has revolutionized cancer research by providing a more accurate representation of the tumor microenvironment (TME) and enabling the study of tumor behavior and response to therapies in a more physiologically relevant context. One of the key benefits of 3D cell culture in cancer research is the ability to recapitulate the complex interactions between cancer cells and their surrounding stroma. Tumors consist not only of cancer cells but also various other cell types, including stromal cells, immune cells, and blood vessels. These models bridge traditional 2D cell cultures and animal models, offering a cost-effective, scalable, and ethical alternative for preclinical research. As the field advances, 3D cell cultures are poised to play a pivotal role in understanding cancer biology and accelerating the development of effective anticancer therapies. This review article highlights the key advantages of 3D cell cultures, progress in the most common scaffold-based culturing techniques, pertinent literature on their applications in cancer research, and the ongoing challenges. Graphical Abstract 

Scaffold-based 3D cell culture models in cancer research

/pdf/recent-advances-on-carbazole-based-oxime-esters-as-3q0m4fcu.pdf

Recent advances on carbazole-based oxime esters as photoinitiators of polymerization

Investigation on moisture damage resistance of asphalt pavement in salt and acid erosion environments based on Multi-scale analysis

/pdf/recent-advances-on-visible-light-coumarin-based-oxime-esters-2a9ac9ad.pdf

Recent Advances on Visible Light Coumarin-based Oxime Esters as Initiators of Polymerization

A Review on Recently Proposed Oxime Ester Photoinitiators

Currently, increasing attention has been focused on light-emitting diodes (LEDs)-induced photopolymerization. The common LEDs (e.g., LED at 365 nm and LED at 405 nm) possess narrow emission bands. Due to their light absorption properties, most commercial photoinitiators are sensitive to UV light and cannot be optimally activated under visible LED irradiation. Although many photoinitiators have been designed for LED-induced free radical polymerization and cationic polymerization, there is still the issue of the mating between photoinitiators and LEDs. Therefore, the development of novel photoinitiators, which could be applied under LED irradiation, is significant. Many photoinitiating systems have been reported in the past decade. In this review, some recently developed photoinitiators used in LED-induced photopolymerization, mainly in the past 5 years, are summarized and categorized as Type Ⅰ photoinitiators, Type Ⅱ photoinitiators, and dye-based photoinitiating systems. In addition, their light absorption properties and photoinitiation efficiencies are discussed.

/pdf/high-performance-photoinitiating-systems-for-led-induced-up0mkpci.pdf

High-Performance Photoinitiating Systems for LED-Induced Photopolymerization

PEDOT:PSS (polyethylene dioxythiophene:polystyrenesulfonate) is a commonly used hole injection layer (HIL) in optoelectronic devices due to its high conductive properties and work function. However, the acidic and hygroscopic nature of PEDOT:PSS can be problematic for device stability over time. To address this issue, in this study we demonstrated the potential of an organic–inorganic hybrid HIL by incorporating solution-processed WOx nanoparticles (WOx NPs) into the PEDOT:PSS mixture. This hybrid solution was found to have a superior hole transport ability and low Ohmic contact resistance contributing to higher brightness (~62,000 cd m−2) and current efficiency (13.1 cd A−1) in the manufactured quantum-dot-based light-emitting diodes (QLEDs). In addition, the resulting devices achieved a relative operational lifetime of 7071 h, or approximately twice that of traditional QLEDs with PEDOT:PSS HILs. The proposed method is an uncomplicated, reliable, and low-cost way to achieve long operational lifetimes without sacrificing efficiency in optoelectronic devices.

/pdf/enhanced-performances-of-quantum-dot-light-emitting-diodes-k6ocixwm.pdf

Enhanced Performances of Quantum Dot Light-Emitting Diodes with an Organic–Inorganic Hybrid Hole Injection Layer

To effectively evaluate the high-temperature characteristics of a fuel-resistant modified asphalt (FRMA), five different types of asphalt were selected, and a fuel-resistant modifier (FRM) was added to the asphalt to prepare five kinds of FRMA, and the fuel resistance of the 10 above-mentioned asphalt samples was then evaluated. Moreover, the high-temperature performance of different asphalt samples was explored, the influences of the FRM on the penetration, softening point, and rheological indexes of the different asphalt samples were analyzed. A Pearson correlation analysis was conducted on the different high-temperature indexes. Based on the results, compared with the original asphalt, the fuel resistance of the FRMA was improved by about 22% on average; the FRM was able to reduce the penetration, phase angle, and non-recoverable creep compliance of the asphalt; increase the softening point, complex modulus, rutting factors, and creep recovery; and effectively improve the high-temperature performance of the asphalt. However, as the temperature increased, the effect of the FRM on the improvement of the high-temperature performance of the asphalt declined. In addition, compared with the base asphalt, the FRM exerted a more significant effect on the rheological properties of the modified asphalt. According to the Pearson correlation analysis of the high-temperature indexes, apart from penetration, the softening point and rheological indexes featured excellent accuracy and applicability in the evaluation of the high-temperature performance of FRMAs.

Effects of a Fuel-Resistant Modifier on the High-Temperature Characteristics of Asphalt Binders

A series of 50 oxime esters bearing various substituents were designed and synthesized as photoinitiators (48 of them were never synthesized before and only B1 and B10 were reported). Good light absorption properties in the visible range were observed for these oxime esters. Some structures exhibited better photoinitiation abilities than diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) upon exposure to a LED@405 nm. Interestingly, PIs with methyl substituent on the oxime ester group have better photoinitiation performance than the others. Substituent effects were investigated through molecular orbitals calculations, the detection of CO2, and the investigation of the generated free radicals. The results demonstrate that the substituents on the oxime ester group exert major effects on the photoinitiation ability via the decarboxylation reaction. In addition, a chemical mechanism was proposed. 3D printed objects were successfully obtained by using the most reactive oxime ester as photoinitiator, and their thermal initiation behaviors of several oxime esters were also studied (dual thermal/photochemical initiator behavior). 

/pdf/effect-of-decarboxylation-on-the-photoinitiation-behavior-of-gxpxio6y.pdf

Effect of Decarboxylation on the Photoinitiation Behavior of Nitrocarbazole-Based Oxime Esters

A test method to evaluate the fuel oil corrosion resistance of asphalt binders

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