Shaobo Wang
University of California, San Diego
14 Papers
1 Citations
Shaobo Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Messenger RNA. The author has an hindex of 5, co-authored 8 publications.
Chat about Author
Papers
Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol.
Shaobo Wang,Wanyu Li,Hui Hui,Shashi Kant Tiwari,Qiong Zhang,Ben A. Croker,Stephen A. Rawlings,Davey M. Smith,Aaron F. Carlin,Tariq M. Rana +9 more
TL;DR: Results shed light on a potentially broad antiviral mechanism by 25HC through depleting accessible cholesterol on the plasma membrane to suppress virus–cell fusion and provide a potential therapeutic candidate for COVID‐19 and emerging viral diseases in the future.
267
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids.
TL;DR: In this article, the authors generated human induced pluripotent stem cell (iPSC)-derived lung organoids (LORGs), cerebral organoid (CORGs), neural progenitor cells (NPCs), neurons, and astrocytes.
114
Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy
Shaobo Wang,Qiong Zhang,Shashi Kant Tiwari,Gianluigi Lichinchi,Edwin Yau,Hui Hui,Wanyu Li,Frank B. Furnari,Tariq M. Rana +8 more
TL;DR: A CRISPR-Cas9 genome-wide screen in glioblastoma stem cells is performed and integrin αvβ5 is identified as an internalization factor for Zika virus, providing a promising therapeutic target, as well as two drug candidates for prophylactic use or treatments for ZIKV infections.
85
Discovery and Mechanism of SARS-CoV-2 Main Protease Inhibitors.
Sarah E. Huff,Indrasena Reddy Kummetha,Shashi Kant Tiwari,Matthew B. Huante,Alex E. Clark,Shaobo Wang,William Bray,Davey M. Smith,Aaron F. Carlin,Mark A. Endsley,Tariq M. Rana +10 more
TL;DR: Wang et al. as mentioned in this paper identified a 2-phenyl-1,2-benzoselenazol-3-one class of compounds targeting the SARS-CoV-2 main protease (Mpro).
An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics.
TL;DR: Analysis of single-cell RNA sequencing of peripheral blood mononuclear cells provides a comprehensive analysis of gene signatures associated with immune cell exhaustion during HIV infection, which could be useful in understanding exhaustion mechanisms and developing new cure therapies.
70