Shaobin Lin
Boston Children's Hospital
22 Papers
28 Citations
Shaobin Lin is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Exome sequencing & Biology. The author has an hindex of 10, co-authored 19 publications.
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Papers
TSGA10 is a novel candidate gene associated with acephalic spermatozoa.
Yanwei Sha,Yan-Kun Sha,Zhi-Yong Ji,Libin Mei,Lu Ding,Qing Zhang,Ping-Ping Qiu,Shaobin Lin,Xu Wang,Ping Li,Xiaohui Xu,Lin Li +11 more
TL;DR: A 27 years old infertile male from a consanguineous family, who presented with 99% headless sperm in his ejaculate is reported, suggesting the presence of rare sequence variants within TSGA10 may be associated with acephalic spermatozoa in humans.
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DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella
Yang Li,Yanwei Sha,Xiong Wang,Lu Ding,Wensheng Liu,Zhi-Yong Ji,Libin Mei,Xianjing Huang,Shaobin Lin,Shuangbo Kong,Jinhua Lu,Weibing Qin,Xinzhong Zhang,Jianmin Zhuang,Yunge Tang,Zhongxian Lu +15 more
TL;DR: The data suggest that the DNAH2 mutation can cause severe sperm flagella defects that damage sperm motility, and provides a novel genetic pathogeny for the human MMAF phenotype.
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Loss-of-function mutations in SPEF2 cause multiple morphological abnormalities of the sperm flagella (MMAF)
Wensheng Liu,Yanwei Sha,Yang Li,Libin Mei,Shaobin Lin,Xianjing Huang,Jinhua Lu,Lu Ding,Shuangbo Kong,Zhongxian Lu +9 more
TL;DR: It is indicated that loss-of-function mutations in the SPEF2 gene can cause the MMAF phenotype in human, a kind of severe teratozoospermia.
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A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review
Yanwei Sha,Liang-Kai Zheng,Zhi-Yong Ji,Libin Mei,Lu Ding,Shaobin Lin,Xu Wang,Xiaoyu Yang,Ping Li +8 more
TL;DR: This study and previous literature indicate that TEX11 mutations are closely associated with male infertility, especially azoospermia, although auxiliary clinical analyses are needed to figure out the causes of male infertility.
Biallelic mutations of CFAP74 may cause human primary ciliary dyskinesia and MMAF phenotype
Yanwei Sha,Xiaoli Wei,Lu Ding,Zhi-Yong Ji,Libin Mei,Xianjing Huang,Zhi-Ying Su,Wenrong Wang,Xuequan Zhang,Shaobin Lin +9 more
TL;DR: This study is the first to identify the importance of CFAP74 in potential PCD and MMAF, contributing to the genetic diagnosis of these disorders and helping to predict pregnancy outcomes relevant in in vitro fertilization.
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