Shane D. Hellyer
Monash University
25 Papers
3 Citations
Shane D. Hellyer is an academic researcher from Monash University. The author has contributed to research in topics: Allosteric regulation & Allosteric modulator. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of Shane D. Hellyer include University of Otago.
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Papers
Marine algal pinnatoxins E and F cause neuromuscular block in an in vitro hemidiaphragm preparation
TL;DR: Results show that pinn atoxins E and F block neuromuscular transmission and suggest that observed in vivo muscle paralysis by pinnatoxin is due to selective antagonism of muscle type nicotinic acetylcholine receptors.
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"Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
Shane D. Hellyer,Sabine Albold,Taide Wang,Amy N. Y. Chen,Lauren T. May,Katie Leach,Karen J. Gregory +6 more
TL;DR: It is found that for many class C GPCR allosteric modulators, subtype selectivity is driven by cooperativity and misinterpreted owing to unappreciated bias.
27
Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology
Kathy Sengmany,Shane D. Hellyer,Sabine Albold,Taide Wang,P. Jeffrey Conn,Lauren T. May,Arthur Christopoulos,Katie Leach,Karen J. Gregory +8 more
TL;DR: The inherent complexity in mGlu5 NAM pharmacology is highlighted that may influence interpretation when translating into preclinical models and beyond in the design and development of novel therapeutics for neuropsychiatric and neurological disorders.
20
Neuromuscular blocking activity of pinnatoxins E, F and G.
TL;DR: Results show that pinnatoxins E, F and G are all potent neuromuscular blocking agents and cause toxicity by acting as antagonists at muscle type nicotinic acetylcholine receptors.
20
Metabotropic glutamate receptor 5 (mGlu5 )-positive allosteric modulators differentially induce or potentiate desensitization of mGlu5 signaling in recombinant cells and neurons.
TL;DR: Data indicate that biased mGlu5 allosteric modulator pharmacology extends to receptor regulatory processes in a tissue dependent manner, adding yet another layer of complexity to rational mGLU5 drug discovery.
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