Shamik Mascharak
Stanford University
58 Papers
69 Citations
Shamik Mascharak is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Fibrosis. The author has an hindex of 11, co-authored 37 publications.
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Papers
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
Shamik Mascharak,Heather E. desJardins-Park,Michael F. Davitt,Michelle Griffin,Mimi R. Borrelli,Alessandra L. Moore,Kellen Chen,Bryan Duoto,Malini Chinta,Deshka S. Foster,Abra H. Shen,Michael Januszyk,Sun Hyung Kwon,Gerlinde Wernig,Derrick C. Wan,H. Peter Lorenz,Geoffrey C. Gurtner,Michael T. Longaker +17 more
TL;DR: In this paper, the authors identify a dermal ENF subpopulation that gives rise to postnatally derived EPFs by activating Engrailed-1 expression during adult wound healing.
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Wound healing, fibroblast heterogeneity, and fibrosis.
TL;DR: Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis, and the mechanisms by which they contribute to both physiologic and pathologic states of extracellular matrix deposition and remodeling are just starting to be understood as mentioned in this paper .
301
Aged skeletal stem cells generate an inflammatory degenerative niche.
Thomas H. Ambrosi,Owen Marecic,Adrian McArdle,Rahul Sinha,Gunsagar S. Gulati,Xinming Tong,Yuting Wang,Holly Steininger,Malachia Y. Hoover,Lauren S. Koepke,Matthew P. Murphy,Jan Sokol,Eun Young Seo,Ruth Tevlin,Michael Lopez,Rachel E. Brewer,Shamik Mascharak,Laura Lu,Oyinkansola Ajanaku,Stephanie D. Conley,Jun Seita,Maurizio Morri,Norma Neff,Debashis Sahoo,Fan Yang,Irving L. Weissman,Michael T. Longaker,Charles Chan +27 more
TL;DR: This paper showed that intrinsic ageing of SSCs in mice alters signalling in the bone marrow niche and skews the differentiation of bone and blood lineages, leading to fragile bones that regenerate poorly.
236
Understanding the impact of fibroblast heterogeneity on skin fibrosis
Michelle Griffin,Heather E. desJardins-Park,Shamik Mascharak,Mimi R. Borrelli,Michael T. Longaker +4 more
TL;DR: The multifaceted aspects of fibroblast heterogeneity and the different roles of Fibroblast subpopulations to help overcome skin scarring and fibrosis are discussed.
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing.
Shamik Mascharak,Heather E. Talbott,Michael Januszyk,Michelle Griffin,Kellen Chen,Michael F. Davitt,Janos Demeter,Dominic Henn,Clark A. Bonham,Deshka S. Foster,Nancie Mooney,Ran Cheng,Peter K. Jackson,Derrick C. Wan,Geoffrey C. Gurtner,Michael T. Longaker +15 more
TL;DR: The divergent molecular events driving skin wound cells toward scarring or regenerative fates are reported and Trps1 is identified as a key regulatory gene that is necessary and partially sufficient for wound regeneration.
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