Shaleen Shrestha
University of Massachusetts Medical School
13 Papers
3 Citations
Shaleen Shrestha is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Shaleen Shrestha include Boston University.
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Papers
Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics
Aurian P. García-González,Ashlyn D. Ritter,Shaleen Shrestha,Erik C. Andersen,L. Safak Yilmaz,Albertha J.M. Walhout +5 more
TL;DR: Surprisingly, it is found that 5-FU and FUDR act through bacterial ribonucleotide metabolism to elicit their cytotoxic effects in C. elegans rather than by thymineless death or DNA damage.
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Enhanced yeast one-hybrid assays for high-throughput gene-centered regulatory network mapping
John S. Reece-Hoyes,Alos Diallo,Bryan R. Lajoie,Amanda Kent,Shaleen Shrestha,Sreenath Kadreppa,Colin Pesyna,Job Dekker,Chad L. Myers,Albertha J.M. Walhout +9 more
TL;DR: It is demonstrated that eY1H assays provide excellent coverage and identify interacting transcription factors for multiple DNA fragments in a short time and will be an important tool for mapping gene regulatory networks in Caenorhabditis elegans and other model organisms as well as in humans.
Human Gene-Centered Transcription Factor Networks for Enhancers and Disease Variants
Juan I. Fuxman Bass,Nidhi Sahni,Shaleen Shrestha,Aurian P. García-González,Akihiro Mori,Numana Bhat,Song Yi,David E. Hill,Marc Vidal,Albertha J.M. Walhout,Albertha J.M. Walhout +10 more
TL;DR: eY1H assays are established as a powerful addition to the toolkit of mapping human GRNs and for the high-throughput characterization of genomic variants that are rapidly being identified by genome-wide association studies.
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PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions.
Alex M. Tamburino,Ebru Kaymak,Shaleen Shrestha,Amy D. Holdorf,Sean P. Ryder,Albertha J.M. Walhout +5 more
- 28 Feb 2017
TL;DR: PRIMA is a translation-based assay that examines interactions in the yeast cytoplasm, the cellular location of mRNA translation, and faithfully recapitulated numerous well-characterized RNA-RBP interactions and also identified novel interactions, some of which were confirmed in vivo.
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PRIMA: a gene-centered, RNA-to-protein method for mapping RNA-protein interactions
Alex M. Tamburino,Ebru Kaymak,Shaleen Shrestha,Amy D. Holdorf,Sean P. Ryder,Albertha J.M. Walhout +5 more
TL;DR: PRIMA is a translation-based assay that examines interactions in the yeast cytoplasm, the cellular location of mRNA translation, and faithfully recapitulates numerous well-characterized RNA-RBP interactions and also identified novel interactions, some of which were confirmed in vivo.
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