Shai Kellner
Technion – Israel Institute of Technology
7 Papers
2 Citations
Shai Kellner is an academic researcher from Technion – Israel Institute of Technology. The author has contributed to research in topics: NMDA receptor & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle
Samah Neame,Hazem Safory,Inna Radzishevsky,Ayelet Touitou,Francesco Marchesani,Marialaura Marchetti,Shai Kellner,Shai Berlin,Veronika N. Foltyn,Simone Engelender,Jean-Marie Billard,Herman Wolosker +11 more
TL;DR: It is found that the synaptic NMDAR activation in adult SR-knockout (KO) mice requires Phgdh-derived glycine, despite the sharp decline in the postnatal glycine levels as a result of the emergence of the glycine cleavage system.
112
Two-Photon Excitation of Azobenzene Photoswitches for Synthetic Optogenetics
Shai Kellner,Shai Berlin +1 more
TL;DR: An overview of recent efforts devoted towards optimizing azobenzene-based photoswitches for 2PE and their current applications is provided.
25
Two extreme Loss-of-Function GRIN2B-mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate
Shai Kellner,Shai Berlin +1 more
TL;DR: In this paper , the effect of GRIN2B mutations on the function of tri-heteromeric NMDARs has been investigated in vitro and postnatally, and the results highlight the importance of examining how different mutations affect features in various receptor subtypes, as these could not have been deduced from observations performed on purely di-heteromers.
Rescuing tri-heteromeric NMDA receptor function: the potential of pregnenolone-sulfate in loss-of-function GRIN2B variants
Shai Kellner,Shai Berlin +1 more
- 25 May 2024
TL;DR: This study investigates the impact of GRIN2B variants on tri-heteromeric NMDA receptor function, revealing a dominant negative effect on glutamate potency, but improved potency with pregnenolone-sulfate (PS) modulation, suggesting potential therapeutic applications for GRINopathies.
2
A novel polycistronic method tailored for engineering split GECIs
Shunit Olszakier,Wessal Hussein,Ronit Heinrich,Michael Andreyanov,Yara Otor,Jackie Schiller,Shai Kellner,Shai Berlin +7 more
TL;DR: In this article , the feasibility of using stop-codons as a means to obtain polycistronic expression in eukaryotic cells was assessed and a technicolor Genetically-Encoded Functional Rainbow Indicators (GEFRIs) for monitoring cellular morphology and neuronal firing was developed.