Severino Urban
Heidelberg University
5 Papers
Severino Urban is an academic researcher from Heidelberg University. The author has contributed to research in topics: Hippocampal formation & Biology. The author has an hindex of 5, co-authored 5 publications.
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Papers
YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
Xiaohong Wang,Aida Freire Valls,Aida Freire Valls,Géza Schermann,Ying Shen,Iván M. Moya,Laura Castro,Severino Urban,Gergely Solecki,Frank Winkler,Lars Riedemann,Rakesh K. Jain,Massimilano Mazzone,Thomas Schmidt,Tamás Fischer,Tamás Fischer,Georg Halder,Carmen Ruiz de Almodovar +17 more
TL;DR: YAP/TAZ are identified as central mediators of VEGF signaling and therefore as important regulators of angiogenesis and thus establish a feedforward loop that ensures a proper angiogenic response.
328
Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma
Tobias Kessler,Felix Sahm,Felix Sahm,Jonas Blaes,Matthias Osswald,Matthias Osswald,Petra Rübmann,David Milford,Severino Urban,Leonie Jestaedt,Sabine Heiland,Martin Bendszus,Anne Hertenstein,Anne Hertenstein,Philipp Niclas Pfenning,Carmen Ruiz de Almodovar,Antje Wick,Frank Winkler,Frank Winkler,Andreas von Deimling,Andreas von Deimling,Michael Platten,Michael Platten,Wolfgang Wick,Wolfgang Wick,Markus Weiler,Markus Weiler +26 more
TL;DR: Conclusively, expression of VEGFR-2 in glioma cells indicates an aggressive glioblastoma subgroup developing early resistance to temozolomide or bevacizumab.
Neuronal LRP4 regulates synapse formation in the developing CNS
Andromachi Karakatsani,Andromachi Karakatsani,Nicolás Marichal,Severino Urban,Georgios Kalamakis,Alexander Ghanem,Anna Schick,Yina Zhang,Karl-Klaus Conzelmann,Markus A. Rüegg,Benedikt Berninger,Carmen Ruiz de Almodovar,Susan Gascon,Susan Gascon,Stephan Kröger +14 more
TL;DR: Overexpression and knockdown of LRP4 in mouse cortical and hippocampal neurons both in vitro and in vivo reveals a key role for LRP3 in dendrite and synapse formation during development, demonstrating an essential and novel role of neuronal L RP4 in dendedritic development and synaptogenesis in the CNS.
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VEGF/VEGFR2 signaling regulates hippocampal axon branching during development.
Robert Luck,Severino Urban,Andromachi Karakatsani,Eva Harde,Eva Harde,Sivakumar Sambandan,LaShae Nicholson,LaShae Nicholson,Silke Haverkamp,Rebecca Mann,Ana Martin-Villalba,Erin M. Schuman,Amparo Acker-Palmer,Amparo Acker-Palmer,Carmen Ruiz de Almodovar +14 more
TL;DR: It is shown that VEGF and its receptor VEGFR2 (also known as KDR or FLK1) are expressed in mouse hippocampal neurons during development, with V EGFR2 locally expressed in the CA3 region.
EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development
Eva Harde,Eva Harde,LaShae Nicholson,LaShae Nicholson,Beatriz Furones Cuadrado,Diane Bissen,Diane Bissen,Sylvia Wigge,Severino Urban,Marta Segarra,Carmen Ruiz de Almodovar,Amparo Acker-Palmer +11 more
TL;DR: The results demonstrate the functional crosstalk of VEGFR2 and ephrinB2 in vivo to control dendritic arborization, spine morphogenesis and hippocampal circuitry development.