Setsuya Aiba
Tohoku University
534 Papers
3.8K Citations
Setsuya Aiba is an academic researcher from Tohoku University. The author has contributed to research in topics: Medicine & Antigen. The author has an hindex of 50, co-authored 525 publications. Previous affiliations of Setsuya Aiba include Uniformed Services University of the Health Sciences & National Institute of Advanced Industrial Science and Technology.
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Papers
Dendritic cell activation induced by various stimuli, e.g. exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix
Setsuya Aiba,Hachiro Tagami +1 more
TL;DR: What kinds of stimuli effectively activate DCs are discussed, such as microorganisms, cytokines, adhesion to extracellular matrix, and simple chemicals like haptens, which is also called as DC maturation.
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Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays
Kyoko Tsujita-Inoue,Morihiko Hirota,Takao Ashikaga,Tomomi Atobe,Hirokazu Kouzuki,Setsuya Aiba +5 more
TL;DR: It is concluded that ANN analysis of data from multiple in vitro assays is a useful approach for risk assessment of chemicals for skin sensitization.
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Tumor-associated M2 macrophages in mycosis fungoides acquire immunomodulatory function by interferon alpha and interferon gamma
TL;DR: The data suggest one possible mechanism of the therapeutic effects of IFNs through TAMs for the treatment of advanced-stage MF through the modulation of M2 macrophages through IL-4 stimulation.
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p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells.
Satoshi Nakagawa,Tomoyuki Ohtani,Masato Mizuashi,Zia U.A. Mollah,Yumiko Ito,Hachiro Tagami,Setsuya Aiba +6 more
TL;DR: A dual effect of UVB, to stimulate maturation or to induce apoptosis in MoDC, depending on the dosage, via p38 MAPK pathway is revealed.
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Significance of immunosuppressive cells as a target for immunotherapies in melanoma and non-melanoma skin cancers
Taku Fujimura,Setsuya Aiba +1 more
- 22 Jul 2020
TL;DR: Tumor-associated macrophages-related factors could offer a biomarker for anti-PD1 Ab-based immunotherapy because of their role in promoting tumor development and the crosstalk between TAMs and immunosuppressive cells.
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