Seth B. Krantz
NorthShore University HealthSystem
36 Papers
115 Citations
Seth B. Krantz is an academic researcher from NorthShore University HealthSystem. The author has contributed to research in topics: Pancreatic cancer & Medicine. The author has an hindex of 14, co-authored 32 publications. Previous affiliations of Seth B. Krantz include Northwestern University.
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Papers
Crosstalk between Mast Cells and Pancreatic Cancer Cells Contributes to Pancreatic Tumor Progression
Matthew J. Strouch,Eric C. Cheon,Mohammad R. Salabat,Seth B. Krantz,Elias Gounaris,Laleh G. Melstrom,Surabhi Dangi-Garimella,Edward Wang,Hidayatullah G. Munshi,Khashayarsha Khazaie,David J. Bentrem,David J. Bentrem +11 more
TL;DR: Tumor-infiltrating mast cells are associated with worse prognosis in pancreatic cancer and in vitro, the interaction between mast cells and Pancreatic cancer cells promotes tumor growth and invasion.
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Three dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2
Surabhi Dangi-Garimella,Seth B. Krantz,Morgan R. Barron,Mario A. Shields,Michael J. Heiferman,Paul J. Grippo,David J. Bentrem,Hidayatullah G. Munshi +7 more
TL;DR: It is shown that the type I collagen allows PDAC cells to override checkpoint arrest induced by gemcitabine, and it is suggested that targeting MT1-MMP could be a novel approach to sensitize pancreatic tumors to gem citabine.
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In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction.
Nichole R. Blatner,Andreas Bonertz,Andreas Bonertz,Philipp Beckhove,Philipp Beckhove,Eric C. Cheon,Seth B. Krantz,Matthew J. Strouch,Juergen Weitz,Moritz Koch,Amy L. Halverson,David J. Bentrem,David J. Bentrem,Khashayarsha Khazaie +13 more
TL;DR: MC induce Treg to switch function and escalate inflammation in CRC without losing T-cell–suppressive properties and IL6 and IL17 are not needed in this process.
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Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion
Mario A. Shields,Surabhi Dangi-Garimella,Seth B. Krantz,David J. Bentrem,David J. Bentrem,Hidayatullah G. Munshi,Hidayatullah G. Munshi +6 more
TL;DR: The data demonstrate that pancreatic cancer cells increase Snail on encountering collagen-rich milieu and suggest that the desmoplastic reaction actively contributes to PDAC progression, and indicates that Snail can regulate MT1-MMP.
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Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.
Mario A. Shields,Seth B. Krantz,David J. Bentrem,Surabhi Dangi-Garimella,Hidayatullah G. Munshi +4 more
TL;DR: Differential effects of Snails and Slug in pancreatic cancer are demonstrated and the interplay between Rho signaling and β1-integrin that functions to regulate the differential scattering and migration of Snail- and Slug-expressing pancreaticcancer cells is identified.
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