Seth A. Brooks
Dartmouth College
15 Papers
60 Citations
Seth A. Brooks is an academic researcher from Dartmouth College. The author has contributed to research in topics: Tristetraprolin & Messenger RNA. The author has an hindex of 11, co-authored 15 publications. Previous affiliations of Seth A. Brooks include United States Department of Veterans Affairs & Veterans Health Administration.
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Papers
Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action.
TL;DR: This review focuses on one of the best characterized ARE binding proteins, tristetraprolin (TTP), the founding member of a small family of CCCH tandem zinc finger proteins, and discusses emerging evidence for TTP operating as a translational regulator.
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The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway.
TL;DR: TTP regulates its own expression in a manner identical to that seen with the TNF-α 3′ untranslated region, indicating that this autoregulation is mediated at the level of mRNA stability.
CARHSP1 Is Required for Effective Tumor Necrosis Factor Alpha mRNA Stabilization and Localizes to Processing Bodies and Exosomes
Jason R. Pfeiffer,Bethany L. McAvoy,Bethany L. McAvoy,Ryan E. Fecteau,Ryan E. Fecteau,Kristen M. Deleault,Kristen M. Deleault,Seth A. Brooks,Seth A. Brooks +8 more
TL;DR: CARHSP1 is concluded to be a TNF-α mRNA stability enhancer required for effective Tumor necrosis factor alpha production, demonstrating the importance of both stabilization and destabilization pathways in regulating the T NF- α mRNA half-life.
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Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity
Regina S. Salvat,Deeptak Verma,Andrew S. Parker,Jack R Kirsch,Seth A. Brooks,Chris Bailey-Kellogg,Karl E. Griswold +6 more
TL;DR: It is demonstrated that a multiobjective library-design method enables incorporation of mutations throughout the protein, modifying portions that trigger immune recognition while simultaneously preserving stability and catalytic activity, and could enable functional deimmunization of other biotherapeutic agents.
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Globally deimmunized lysostaphin evades human immune surveillance and enables highly efficacious repeat dosing
Hongliang Zhao,Seth A. Brooks,Susan K. Eszterhas,Spencer Heim,Liang Li,Yan Q. Xiong,Yongliang Fang,Jack R Kirsch,Deeptak Verma,Chris Bailey-Kellogg,Karl E. Griswold +10 more
TL;DR: A deimmunized lysostaphin biotherapy evades detrimental antidrug immune reactions and has improved efficacy for MRSA infections, providing significant anti-MRSA protection for animals that were immune experienced to the wild-type enzyme.
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